ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK

在青少年保健和健康（REACH）项目达到卓越 是一项由美国国立卫生研究院资助的多中心纵向研究。 儿童健康和人类发展（NICHD），国家研究所 过敏和传染病（NIAID），国家药物研究所 滥用（NIDA）和卫生资源和服务管理局（HRSA） 从医学、生物行为和心理学方面研究 受感染青少年的艾滋病毒/艾滋病，包括获得护理和使用护理的机会 通过性行为或吸毒行为感染艾滋病毒。 约240名艾滋病毒感染者- 12 - 18岁的HIV阳性和120例HIV阴性受试者， 招募到本方案中，该方案将测量健康状况、服务 利用，性和吸毒行为，性传播 疾病和病毒合并感染以及心理状态。 受试者将 在项目期间每隔三个月进行一次。的 该项目的最终目标是更好地了解艾滋病毒 青少年的疾病进展和合并症，从而改善 保健管理。 这一目标将通过初步 大约200名感染艾滋病毒的青少年参加了一个 标准化基本协议来表征基于群体的频谱 疾病、疾病进展以及与其他疾病的共病影响 性传播疾病和青少年怀孕; 以及卫生保健服务的标准化和评估。 的 该项目的目标是研究艾滋病毒的发病机制 感染，包括疾病谱，治疗和未治疗 12-18岁青少年的艾滋病毒感染的发病机制， 青少年与成人和儿童的描述相似。审查 HIV感染对正常生理生长和发育的影响 艾滋病病毒感染的青少年中， 性传播疾病，通常发生在青少年和 比较HIV阳性和HIV阴性的发病率 青少年，心理健康对疾病进展的作用，以及 潜在的免疫学和免疫遗传学标志物或疾病进展 特别是感染艾滋病毒的青少年。

The Reaching for Excellence in Adolescent Care and Health (REACH) Project is a ulticenter longitudinal study funded by the National Institute of Child Health and Human Development (NICHD), the National Institute of Allergy and Infectious Disease (NIAID), the National Institute on Drug Abuse (NIDA), and the Health Resources and Services Administration (HRSA) to research the medical, biobehavioral, and psychological aspects of HIV/AIDS, including access to care and its use, in adolescents infected with HIV through sexual or drug-taking behaviors. Approximately 240 HIV- positive and 120 HIV-negative subjects, ages 12 through 18 years, will be recruited into this protocol which will measure health status, service utilization, sexual and and drug-taking behaviors, sexually transmitted disease and viral coinfection, and psychological state. Subjects will be seen at three month intervals over the duration of the project. The ultimate goal of this project is to achieve a better understanding of HIV disease progression and co-morbidity in adolescents and thus improve health care management. This goal will be addressed through the initial enrollment of approximately 200 HIV-infected adolescents into a standardized base protocol to characterize population-based spectrum of disease, disease progression, and the effect of co-morbidity with other sexually-transmitted disease and pregnancy in the adolescent population; and the tandardization and evaluation of health care services. The objectives of this project are to examine the pathogenesis of HIV infection, including spectrum of disease, in treated and untreated adolescents ages 12-18 and to ompare the pathogenesis of HIV infection in adolescents to that described for adults and children. To examine the effects of HIV infection on normal physiologic growth and development in HIV-infected adolescents, the morbidity associated with co-infection with sexually transmitted disease that commonly occur in adolescents and to compare these morbidities between HIV-positive and HIV-negative adolescents, the role of mental health on disease progression, and potential immunologic and immunogenetic markers or disease progression specific to adolescents infected with HIV.