ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER

这里提出了一项关于总多氯联苯、单个多氯联苯的作用的研究 同系物、滴滴涕和灭蚁灵在绝经后乳腺癌病因中的作用。 将对这些环境污染物的血清水平进行评估。在……里面 此外，酶的遗传多态与风险的关联 参与致癌物代谢和解毒(细胞色素P450 谷胱甘肽-S-转移酶) 检查过了。最后，修改关联的效果 具有遗传多态风险的环境污染物将被 评估过了。 这项研究将使用储存、冷冻(零下70摄氏度)的血液样本 作为一项更大的关于饮食、生殖和健康的病例对照研究的一部分收集的 绝经后乳腺癌风险的其他因素。病例(n=150) 原发的，组织学确诊的疾病。人口控制(n=150) 将与年龄、抽血日期和频率相匹配 与家庭以外的其他乳腺癌危险因素的病例匹配 乳腺癌病史。将抽取新的血液样本进行DNA检测 决定。关于疾病前期的采访数据已经收集好了 正常饮食、病史、生育史和家族史 癌症。这项研究为高效的 中国潜在重要环境污染物的检测 结合对遗传易感性和其他已知风险的评估 因素，在美国东北部，一个高风险的地理区域 乳腺癌。

Proposed here is a study of the role of total PCBs, individual PCB congeners, DDT and mirex in the etiology of postmenopausal breast cancer. Serum levels of these environmental contaminants will be evaluated. In addition, the association with risk of genetic polymorphisms of enzymes involved in carcinogen metabolism and detoxification (the cytochrome P450 enzymes CYP2D6 and CYP1A1, and glutathione-S-transferase) will be examined. Finally, effect modification of the association of the environmental contaminants with risk by the genetic polymorphisms will be assessed. This study will use stored, frozen (-70 degrees C) blood specimens collected as part of a larger case-control study of diet, reproductive and other factors in risk of postmenopausal breast cancer. Cases (n= 150) have primary, histologically confirmed disease. Population controls (n= 150) will be matched to cases on age and date of blood draw and frequency matched to cases on other breast cancer risk factors other than family history of breast cancer. New blood samples will be drawn for the DNA determinations. Interview data have already been collected on predisease usual diet, medical history, reproductive history and family history of cancer. This study provides an important opportunity for efficient examination of potentially important environmental contaminants in conjunction with evaluation of genetic susceptibility and other known risk factors, in the northeastern U.S., a geographic region at high risk of breast cancer.