RISK FACTORS FOR CVD IN WOMEN

该计划将继续调查心血管疾病的决定因素 疾病(CVD)在一项长期的大型前瞻性队列研究中， 包括121,700名被跟踪的美国注册女护士 自1976年以来，目前年龄在51-76岁之间。继续跟进将 允许对一些新的和及时的假设进行评估 冠心病(CHD)的饮食和激素危险因素 以及缺血性和出血性中风。此外，还有两项后续行动 新的重要终点、心脏性猝死(SCD)和充血性 心力衰竭(CHF)，将被建立，使他们能够检查 动脉粥样硬化危险因素、体力活动和体重变化的影响 关于SCD的风险，以及实施一种确认CHF的方法。 护士健康研究始于1976年，目的是研究糖尿病的危险因素 乳腺癌。1979年，为心血管疾病的风险因素提供了资金。 每两年邮寄一次的调查问卷收集详细的最新信息 关于大量接触，包括饮食，吸烟，身体 活动、绝经后激素使用、心理社会和行为 各种因素。心肌梗死和中风的事件报告如下 确认通过审查医疗记录进行分类，并类似 程序将延长以确认CHF和SCD。致命的心血管事件有 由死亡证明记录，并经医院复核确认 医疗记录，尸检报告和与亲属的面谈。 随访死亡率超过98%。体型大，前景看好 设计，高随访率，详细可靠的长期暴露 和结果信息，以及血液样本的可用性 庞大的亚群，再加上相对较低的成本，使这一群体 是研究营养学、荷尔蒙和 女性心血管疾病的行为决定因素。继续为这一项目提供资金 Grant将提供有关冠心病风险因素的重要新信息， 中风、SCD和CHF在这群现在进入 心血管疾病成为头号杀手的时代。

The plan is to continue investigation of determinants of cardiovascular disease (CVD) in a large, prospective cohort study of long duration, comprised of 121,700 US female registered nurses who have been followed since 1976 and are currently age 51-76 years. Continued follow-up will permit evaluation of a number of new and timely hypotheses regarding dietary and hormonal risk factors for coronary heart disease (CHD) as well as ischemic and hemorrhagic stroke. In addition, follow-up of two new and important endpoints, sudden cardiac death (SCD) and congestive heart failure (CHF), will be established, allowing them to examine the effect of atherogenic risk factors, physical activity and weight change on risk of SCD, as well as implement a methodology for confirming CHF. The Nurses' Health Study was begun in 1976 to study risk factors for breast cancer. In 1979, funding for risk factors of CVD was secured. Biennial mailed questionnaires gather detailed, updated information about a large number of exposures, including diet, smoking physical activity, postmenopausal hormone use, and psychosocial and behavioral factors. Incident reports of myocardial infarction and stroke are confirmed an classified by review of medical records, and similar procedures will be extended to confirm CHF and SCD. Fatal CVD events are documented by death certificates and confirmed by review of hospital medical records, autopsy reports and interviews with next of kin. Mortality follow-up exceeds 98 percent. The large size, prospective design, high follow-up rates, detailed and reliable long-term exposure and outcome information, and the availability of blood specimens on a large subgroup, combined with the relatively low cost, make this cohort a valuable and unique resource to study nutritional, hormonal and behavioral determinants of CVD in women. Continued funding of this grant will provide important new information about risk factors for CHD, stroke, SCD and CHF in this population of women who are now entering the age where CVD becomes the leading killer.