FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDER

这项研究将确定强迫症(OCD) 是家族血缘关系。考虑到不一致和方法限制， 在之前的研究中，我们建议进行一项盲目、对照的家庭研究。 其他目标包括：确定其他特定的精神病患者 疾病在强迫症先证者的一级亲属中更为普遍 确定人口学和临床特征 区分家族性和散发性(非家族性)强迫症病例；以及 进行偏析分析。 强迫症先驱将在巴尔的摩的四个机构和 一组在年龄、性别和种族上匹配的对照组，将 在每个先证者的住宅区确认。所有的先驱， 控制，他们的一级亲属会直接和盲目地 使用标准化仪器诊断DSM-IIIR轴I和 第二轴精神障碍。最终诊断将以协商一致的方式作出。 两名独立精神病学家审查了所有病例材料，包括 医疗记录。有多个成员患有强迫症的家庭将被 确定了未来可能进行的遗传连锁研究。

This research will establish whether obsessive compulsive disorder (OCD) is familial. Given the inconsistencies and methodological limitations of prior research, we are proposing a blinded, controlled family study. Additional aims include: determining if other specific psychiatric disorders are more prevalent in first-degree relatives of OCD probands than those of controls; identifying demographic and clinical features which distinguish familial from sporadic (non-familial) cases of OCD; and conducting segregation analysis. OCD probands will be identified in four institutions in Baltimore and Washington, D.C. A control group, matched on age, sex, and race, will be identified in the residential neighborhood of each proband. All probands, controls, and their first-degree relatives will be directly and blindly examined using a standardized instrument to diagnose DSM-IIIR Axis I and Axis II psychiatric disorders. Final diagnoses will be made by consensus of two independent psychiatrists reviewing all case material, including medical records. Families with multiple affected members with OCD will be identified to possible future genetic linkage study.