MIAMI AIDS ONCOLOGY SCIENTIST PROGRAM

描述：(申请人描述)抗病毒药物和 抗生素治疗延长了感染人类的人的生存时间 免疫缺陷病毒(HIV)。至少在美国，传染性疾病的数量 然而，并发症减少了，住院人数也下降了， 早期在治疗学(核苷类似物)方面的成就 导致更长的、免疫抑制的生存期，可能是部分原因 艾滋病相关癌症的激增。没有人知道今天的进步 可能会为未来的肿瘤奠定基础。HIV相关的恶性肿瘤是一种 一组全新的肿瘤，表现得比他们的 在艾滋病毒阴性社区中看到的组织学同行。一位肿瘤学家 只接受后者的培训将不足以应对艾滋病的恶变 病人。 艾滋病毒、细胞因子和其他病毒之间的相互作用 开始被赏识了。我们概述了一项培训计划，将需要 培养有前途的青年医生，加强对他们的临床培训 并为艾滋病和相关的恶性肿瘤提供科学指导 在肿瘤免疫学和分子生物学方面有丰富的专业知识。实习生将 有接触到几乎所有的表现形式的优势 在他们发展他们的基础研究项目的同时，他们还在研究逆转录病毒恶性肿瘤。 我们的机构能够满足艾滋病肿瘤学的所有先决条件 培训；大量和多样化的患者群体，新的临床试验，以及 强大的基础科学导师。

DESCRIPTION: (Applicant's Description) The development of antiviral and antibiotic therapy has prolonged survival in those infected with Human Immunodeficiency Virus (HIV). At least in America, the number of infectious complications are fewer and hospital admissions have dropped, however, earlier accomplishments in therapeutics (nucleoside analogues) which resulted in longer, immunosuppressed survival, are likely part of the reason for an upsurge in AIDS associated cancers. No one knows if today's advances may set the stage for future neoplasms. HIV associated malignancies are an entirely new set of tumors which behave much more aggressively than their histologic counterparts seen in the HIV negative community. An oncologist trained only in the latter will be poorly prepared to manage AIDS malignancy patients. The interplay between HIV, cellular factors and other viruses is just starting to be appreciated. We outline a training program which will take promising young physicians, train them intensively in the clinical aspects of AIDS and associated malignancies and provide scientific mentorship with varied expertise in tumor immunology and molecular biology. Trainees will have the advantage of exposure to nearly all of the manifestations of retroviral malignancies while they develop their basic research project. Our institution is able to meet all of the prerequisites of AIDS oncology training; a large and varied patient population, novel clinical trials, and strong basic science mentors.