MEDICATION ADHERENCE INTERVENTION FOR HIV+ PERSONS

调查人员建议利用之前的最佳策略 坚持和行为改变研究发展和干预试验 这将评估144名有困难的艾滋病毒感染男性和女性 坚持他们的抗逆转录病毒方案，谁将被随机分配 两种情况之一：量身定做的行为团体干预 由行为心理学家和护士实习生协助 包括社会支持和患者教育，或标准护理 条件。协议涉及广泛的干预，所以故态复萌 人们认为长期坚持预防是必要的，因此 干预由最初的五个疗程和四个助推器组成 会议随后举行。所有参与者都将在前/后进行评估 干预时间分三个月、九个月、十五个月和二十一个月。 研究的目的是：(1)确定量身定做的行为 包括社会支持和患者干预的干预 组件和维护助推器会议，促进药物治疗 坚持和解决与用药有关的情感问题 HIV阳性者长期随访依从性；(2) 以确定在一段时间内在 干预组；(3)确定药物治疗是否有改善 坚持与较少的情感和行为证据相关 痛苦，和更好的生活质量；(4)探索药物治疗如何 坚持与性传播危险行为有关；以及(5) 探讨服药依从性与潜力之间的关系 调节和调节变量，包括自我效能感和结果 接受与坚持、行为意图、应对方法、 和医疗服务满意度。

The investigators proposed to utilize the best strategies from prior adherence and behavior change research to develop and intervention trial that will evaluate 144 HIV-infected men and women having difficulty adhering to their antiretroviral regimen, who will be randomly assigned to one of two conditions: a tailored behavioral group intervention facilitated by behavioral psychologist and a nurse practitioner which includes social support and patient education, or a standard care condition. The protocol involves an extensive intervention, so relapse prevention is thought to be needed for long term adherence, thus the intervention consists of five sessions initially and four booster sessions subsequently. All participants will be assessed at pre/post- intervention time points at three, nine, fifteen, and twenty-one months. The aims of the study are: (1) to determine whether tailored behavioral intervention that includes social support and patient intervention components, and maintenance booster sessions, promotes medication adherence, and affective problem solving related to medication compliance among HIV positive individuals over long term follow-up; (2) to determine the level of adherence that is maintained over time in the intervention group; (3) to determine if improvement in medication adherence is associated with less evidence of emotional and behavioral distress, and better quality of life; (4) to explore how medication adherence is associated with sexual transmission risk behaviors; and (5) to explore relationships between medication adherence and potential moderating and mediating variables, including self-efficacy and outcome acceptances related to adherence, behavioral intentions, coping methods, and health care satisfaction.