AGE-RELATED SLEEP IMPAIRMENT--POSSIBLE INTERVENTIONS

这是K02 MH01158的重新提交，研究科学家开发 迈克尔·V·维蒂洛博士的获奖申请。 维蒂洛的研究努力集中在了解原因和 与年龄相关的睡眠和昼夜节律变化的后果 为他提供扩展协作关系的机会 并开发与他的研究兴趣相关的其他专业知识。 Vitiello博士建议研究可能的干预措施的可行性 在三个层面上：第一，继续研究健身的影响 训练。老年人睡眠质量与夜间生理的关系； 第二，开始一系列新的研究，旨在评估 合成激素在改善睡眠质量方面的有用性；第三， 发展新型协作关系，最终目标是 探讨改善老年人睡眠质量的可能性 服用褪黑激素。 维蒂洛博士目前正在进行一项关于健身效果的研究 关于老年人睡眠的培训。关于睡眠的初步分析 和健身项目数据集表明，无论是常规耐力还是 伸展/柔韧训练改善患者的客观睡眠质量 健康的老年男女。然而，主观睡眠的改善 质量、昼夜核心体温节律和分泌模式 观察大鼠生长激素和血浆去甲肾上腺素的变化。对此的分析 数据集和与以下项目一起开发的辅助研究的数据集 这项研究将继续进行。 维蒂洛博士还计划研究合成代谢之间的关系 两项研究中的状态和睡眠质量。第一个是相关性研究， 将研究合成代谢状态和睡眠质量之间的关系 在健康的老年男性样本中。第二，前瞻 干预，将检查健康老年男性和 接受生长激素治疗三个月前后的女性 释放因子或安慰剂。 维蒂洛博士还将与罗伯特·萨克博士展开合作，并 发展褪黑激素昼夜节律方面的专业知识，最终目标是 检查内分泌系统作为另一种可能的干预措施 与年龄相关的睡眠障碍。

This is a resubmission for K02 MH01158, a Research Scientist Development Award application for Michael V. Vitiello, Ph.D. It will support Dr. Vitiello's research efforts which center on understanding the causes and consequences of age-related changes in sleep and circadian rhythms and provide him with the opportunity to expand his collaborative relationships and develop additional expertise relevant to his research interests. Dr. Vitiello proposes to examine the feasibility of possible interventions at three levels: first, to continue his study of the effects of fitness training. on the sleep quality and nighttime physiology of the elderly; second, to begin a new series of studies designed to evaluate the usefulness of anabolic hormones in improving sleep quality; and third, to develop a new collaborative relationship with the ultimate goal of examining the possibility of improving the sleep quality of the elderly with melatonin administration. Dr. Vitiello is currently conducting a study of the effects of fitness training on the sleep of the elderly. Preliminary analyses of the sleep and fitness project data set indicate that neither regular endurance nor stretching/flexibility training improves objective sleep quality in healthy elderly men and women. However, improvements in subjective sleep quality, circadian core body temperature rhythm and secretory patterns of growth hormone and plasma norepinephrine were observed. Analyses of this data set and those of the ancillary studies developed in conjunction with this study will continue. Dr. Vitiello also plans to examine the relationship between anabolic status and sleep quality in two studies. The first, a correlational study, will examine the relationships between anabolic status and sleep quality in a sample of healthy elderly men. The second, a prospective intervention, will examine the sleep quality of healthy elderly men and women before and after three months of treatment with growth hormone releasing factor or placebo. Dr. Vitiello will also develop a collaboration with Dr. Robert Sack and develop expertise in the circadian melatonin rhythm with the ultimate goal of examining this endocrine system as another possible intervention for age-related sleep disturbance.