EARLY EXPOSURE TO LEAD AND ADOLESCENT DEVELOPMENT

描述(作者摘要)：目前没有出生队列， 铅暴露对神经心理影响的前瞻性研究 青春期的功能和社会适应。早期领导的作用 青少年神经心理、情绪和社会发展的暴露 在很大程度上是未知的。神经心理功能缺陷，学术 成就和亲社会行为代表着严重的公共健康 美国社会经济上处于不利地位的市中心青年的问题 各州。早期接触铅被认为会导致铅摄入量减少 智力成就和学习问题。此外，这一联系 认知缺陷和反社会行为之间的关系一直很好 已经成立了。因此，据推测，早期铅暴露将是 与执行功能缺陷有关，增加 进攻性-颠覆性的同龄人关系，最终会有更高的 犯罪行为的发生率/流行率。未来的方法论将是 用于评估出生前和出生后早期的远期影响 铅暴露对神经心理缺陷发展的影响(靶向 已知受铅影响的功能以及区分人群 来自非犯罪青少年的犯罪)，同伴关系困难 (利用创新的课堂社交和同伴提名 方法论)、人格障碍(使用标准化的测量方法 个性和自我概念)，以及家庭、学校中的反社会行为 和整个社区(利用父母/监护人告密者和自我 报告)。对大约300名受试者的出生队列进行了跟踪调查 自1980年以来，定期进行血铅浓度评估， 乳牙铅浓度，健康史，社会遗传因素， 和神经行为发育。

DESCRIPTION (Author's Abstract): There are currently no birth cohort, prospective studies of the impact of lead exposure on neuropsychological functioning and social adjustment in adolescence. The role of early lead exposure in adolescent neuropsychological, emotional and social development is largely unknown. Deficits in neuropsychological functioning, academic achievement, and prosocial behavior represent a serious public health problem for socioeconomically disadvantaged, inner-city youth in the United States. Early exposure to lead is believed to result in reduced intellectual attainment and learning problems. Furthermore, the link between cognitive deficits and antisocial behavior has been well established. Therefore, it is hypothesized that early lead exposure will be associated with deficits in executive function, an increase in aggressive-disruptive peer relationships, and ultimately a higher incidence/prevalence of delinquent acts. A prospective methodology will be employed to assess the long-range effects of prenatal and early postnatal lead exposure on the development of neuropsychological deficits (targeting functions known to be affected by lead as well as distinguishing populations of delinquent from non-delinquent youth), difficulties in peer relationships (utilizing innovative classroom sociometric and peer nomination methodologies), personality disturbances (utilizing standardized measures of personality and self-concept), and antisocial behavior in the home, school and community at large (utilizing parental/guardian informants and self reports). This birth cohort of approximately 300 subjects has been followed since 1980 with regularly scheduled assessments of blood lead concentration, deciduous tooth lead concentration, health history, sociohereditary factors, and neurobehavioral development.