CORE--NEUROPSYCHOLOGY

神经心理学核心将促进项目目标的实现 并通过提供 量化所有人的认知和行为特征的资源 帕金森氏病(PD)患者和所有其他年轻人和老年人 受试者接受标准化的神经心理测试。一旦受试者有了 被人类选择在个人项目中进行可能的研究 主题/数据分析核心，神经心理学核心将筛选这些 受试者使用一套简单的神经心理学程序已经在 由MADRC使用。除了这个简短的评估外，所有的受试者 接受L项目的低技术评估(因此正在进行的评估 对低技术任务的高科技分析)将额外管理一套 包括特定行为领域的神经心理测量 感觉与建议的生物力学研究相关(例如， 智力/精神状态，认知，运动能力，情感， 应对/适应。认知领域包括具体的衡量标准 注意力、解决问题、空间能力和精神运动表现。 这项评估将更全面地描述 患者在计划中的能力，扩大了可推广性 这些发现，并允许对这些方面进行更精细的分析 可能与运动控制有关的神经心理表现。在 确定什么是关键的神经心理学的总体目标 可能导致老年人行动不便的因素 神经心理学的核心将是假设驱动的。例如，我们预计 来证明这些认知能力之间越来越强的联系 和行为/情感组件，并成功完成移动性 作为高技术需求的难点和复杂性的任务 任务增多。基本的简单运动和行为/情感组件 预计会对低难度的低技术任务产生影响，而 认知的显著影响有望在以下方面显现出来 高难度的低技术任务。我们希望用我们的客观措施 与观察者评级的仪器相结合的精神运动能力 已通过MADRC标准化使用的运动功能 为了进一步描述帕金森病患者在这方面的功能 计划，并通过对比加深我们对这些措施的理解 向他们提供了低技术和高科技机动性评估的结果。那些 不在项目1中，但正在接受其他高科技的受试者 任务将被给予基本的MADRC筛选电池，以及一组 关于情感和应对/适应的措施。另外，因为之前的 我们节目中的研究表明，更复杂和要求更高的 步态研究，例如那些涉及跨过障碍的研究，可能是 受患者普遍关注的显著影响 将对以下人员实施集中注意措施 项目2中其他高科技任务中的患者测试。最后， 神经心理学核心将帮助提供更全面的验证 整体建议书中个别项目的调查结果，透过 评估所有受试者的一般功能状态。

The Neuropsychology Core will promote the goals of the Program Project and contribute directly to the individual projects by providing the resources for quantifying cognitive and behavioral characteristics of all Parkinson's disease (PD) patients and all other young and elderly subjects by standardized neuropsychological testing. Once subjects have been selected for possible study in the individual projects by the Human Subjects/Data Analysis Core, the Neuropsychology Core will screen these subjects using a brief set of neuropsychological procedures already in use by the MADRC. In addition to this brief assessment, all subjects receiving Project l's Lo-tech evaluations (and therefore those undergoing Hi-tech analyses of Lo-tech tasks) will be administered an additional set of neuropsychological measures including specific domains of behavior felt to be relevant to the proposed biomechanical studies (e.g., Intellect/Mental Status, Cognition, Motor Ability, Affect, Coping/Adaptation. The Cognitive domain includes specific measures of attention, problem solving, spatial ability, and psychomotor performance. This assessment will provide a more comprehensive description of patients' abilities in the Program, broadening the generalizability of the findings, and allow a finer analysis of those aspects of neuropsychological performance that may be tied to motor control. Within the overall goal of determining what are the critical neuropsychological factors that may underlie mobility impairments in the elderly, the Neuropsychology Core will be hypothesis driven. For example, we expect to demonstrate increasingly stronger associations between these cognitive and behavioral/affectual components and successful completion of mobility tasks as the difficulty and complexity of the demands in the Lo-tech tasks increase. Basic simple motor and behavioral/affectual components are expected to exert influence on low-difficulty Lo-tech tasks, whereas significant effects of cognition are expected to be evident on high-difficulty Lo-tech tasks. We expect to use our objective measures of psychomotor ability in conjunction with observer-rated instruments of motor functioning that have been standardized for use through the MADRC to further characterize the functioning of the PD patients in this program and to further our understanding of these measures by contrasting them with the results of the Lo- and Hi-tech mobility assessments. Those subject who are not in Project 1, but who are receiving the Other Hi-tech Tasks will be given the basic MADRC screening battery, as well as a group of measures of affect and coping/adaptation. Also, because previous research in our program has suggested that more complex and demanding gait studies, such as those involving stepping over barriers, may be significantly influenced by a patient's general attention and concentration specific attention measures will be administered to patients in the Other Hi-Tech Tasks testing in Project 2. Finally, the Neuropsychology Core will assist in providing more general validation for findings in individual projects in the overall proposal through an assessment of the general functional status of all subjects.