EFFECT OF NOCTURNAL HYPOTENSION AND INTROCULAR PRESSURE ON NOCTURNAL

本研究将评估非选择性Beta-1的效果。 阻滞剂噻吗洛尔与内源性β受体阻滞剂的比较 拟交感神经活动(ISA)、卡替洛尔对夜间活动变化的影响 血压、夜间心输出量、夜间眼压 (眼压)和视功能。最近的证据表明， 原发性开角型青光眼(POAG)患者中有异常的比例 血压和眼压的变化。外用β受体拮抗剂 是POAG患者降眼压的首选药物。虽然 这些药物的全身性副作用是公认的，即 心率、血压等的降低，它们一般都是 被忽略，因为没有考虑到系统性心血管因素 对这种疾病的发病机制很重要。然而，如果各种测试版- 阻滞剂药物对心血管疾病的影响有很大不同 反过来影响疾病进展的因素，选择 必须包括对每种药物的更严格的审查 全身副作用。

The present study will evaluate the effects of a nonselective beta- blocking agent, timolol, versus a beta-blocker with intrinsic sympathomimetic activity (ISA), carteolol, on the variation of nocturnal blood pressure, nocturnal cardiac output, nocturnal intraocular pressure (IOP) and visual function. Recent evidence has shown that a high percentage of primary open angle glaucoma (POAG) patients have unusual variations in both blood pressure and IOP. Topical beta antagonist agents are the drugs of first choice for lowering IOP in POAG patients. Although the systemic side effects of these agents are well established, ie reduction in heart rate, blood pressure, etc, they have been generally ignored because systemic cardiovascular factors have not been considered important for the pathogenesis of the disease. However, if various beta- blocker drugs have substantially different effects on cardiovascular factors which in turn influence the progression of the disease, selection of a treatment regiment must include a more critical review of each drug's systemic side effects.