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UNMASKING CRF ACTH CORTISOL AXIS IN HYPOTHALAMIC AMENORRHEA

UNMASKING CRF ACTH CORTISOL AXIS IN HYPOTHALAMIC AMENORRHEA
揭示下丘脑性闭经中的 CRF ACTH 皮质醇轴
批准号：
6279191
负责人：
SAMUEL S YEN
金额：
$1.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279191
关键词：
adrenocorticotropic hormone alpha adrenergic receptor amenorrhea clinical research corticotropin releasing factor female gonadotropin releasing factor hormone regulation /control mechanism human subject hypercortisolism hypothalamus luteinizing hormone neuroendocrine system women's health

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中文摘要
翻译
明确女性神经内分泌异常的潜在机制， 功能性下丘脑性闭经，以测试是否发展 闭经时皮质醇血症由下丘脑CRF升高介导 继发于α-肾上腺素能激活和 CRF可抑制GnRH-LH搏动。
英文摘要
Define mechanisms underlying neuroendocrine aberrations in women with functional hypothalamic amenorrhea, to test whether development of hypercortisolemia in amenorrhea is mediated by increased hypothalamic crf secondary to alpha-adrenergic activation and that inappropriate input of CRF may inhibit GnRH-LH pulsatility.
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会议论文
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HORMONE REPLACEMENT AFFECTS ROLE OF DHEA IN WOMEN OF ADVANCED AGE
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