PHYSICAL ACTIVITY AND NIDDM DEVELOPMENT

描述：（改编自研究者摘要） 建议继续研究体力活动在 非胰岛素依赖型糖尿病（NIDDM）的发展， 皮马印第安人口。 研究人员指出，这一努力是 独特之处在于，这是唯一一项正在收集的研究， 人群中的身体活动水平和葡萄糖耐量测量 NIDDM的高风险发展。 调查人员进一步指出， 克里斯卡体力活动问卷收集的数据 在首席研究员的第一个奖项提供了一个独特的机会， 研究体力活动与 葡萄糖耐受不良 与这一人群的横断面调查结果相反， 初步的纵向分析不支持显著的关系 身体活动和NIDDM的发展之间的关系。 这是否 实际上，初步纵向检查是正确的，或者是 功率不足（男性病例不足， 女性的行为（不明确）。 调查人员寻求继续资助 在较长的随访时间内审查这一问题。 的第二目的 这一建议是为了审查活动在发展 Pima印第安人NIDDM常见的各种并发症。 研究者 指出，这项工作是重要的，因为目前所知甚少， 关于身体活动和血压之间的关联， 视网膜病变、高血压、肾病和心血管疾病， 葡萄糖耐受不良的人。

DESCRIPTION: (Adapted from Investigator's Abstract) The purpose of this proposal is to continue to investigate the role of physical (in)activity in the development of non-insulin dependent diabetes mellitus (NIDDM) in the Pima Indian population. The investigator points out that this effort is unique in that this is one of the only studies with an ongoing collection of both physical activity levels and glucose tolerance measures in a population at high risk for the development of NIDDM. The investigator further notes that the data collected with the Kriska physical activity questionnaire during the Principal Investigator's First Award provide a unique opportunity to investigate the longitudinal relationship between physical activity and glucose intolerance. In contradiction to the cross-sectional findings in this population, preliminary longitudinal analyses do not support a significant relationship between physical activity and the development of NIDDM. Whether this initial longitudinal examination is, in fact, correct or is the result of insufficient power (lack of cases in males and lack of range of physical activity in females) is not clear. The investigator seeks continued funding to examine this issue during a longer follow-up time. A second purpose of this proposal is to examine the role of activity in the development of the various complications common to NIDDM in the Pima Indians. The investigator states that this effort is important since little is currently known regarding the association between physical activity and blood pressure, retinopathy, hypertension, nephropathy, and cardiovascular disease in individuals with glucose intolerance.