SOCIODEMOGRAPHIC REGULATION OF CV FUNCTION AND STRUCTURE

描述：拟议研究的目的是建立 与差异表达有关的种族方面 非裔美国人和高加索人的心血管疾病进程 美国人。鉴于人们对环境影响程度的认识不断增强 这些民族通常面临不同的环境影响 这些过程可能是一个重要因素，也是种族的一个方面。 社会经济地位(SES)是这种环境的一个有用的指数，并且是 与心血管疾病(CVD)相关。因为行为是一条途径 SES的影响被认为通过疾病来表达，这 该提案特别关注压力反应性，这被认为是 与心血管疾病的病理生理学有关。因为这种疾病有它的 在儿童时期，将使用多民族的儿科样本。 此外，受试者样本将由双胞胎组成。对这一事件的调查 环境对心血管疾病表达的影响只有在 对生物影响的适当控制。 480对双胞胎将参观实验室。一半的人 配对将是非洲裔美国人，一半是高加索裔美国人；男性和 女性将获得平等的代表权。受试者将完成三门课程 实验室压力源：电子游戏任务，有组织的社交访谈，以及 冷增压机。将评估压力响应性，特别是 支付给全身血管阻力(SVR)的利息。左心室 还将评估质量(LVM)。复杂的环境和 遗传信息分析将允许对环境进行量化 对SVR响应能力和LVM的影响。据推测，环境问题 影响(SE)将在以下变化中占更大比例 非洲裔美国人的SVR反应性和LVM高于高加索裔美国人。这个 假设SVR响应性是SES行使其 还将测试对LVM的影响。 长期目标是为了更好地了解 环境对心血管疾病的影响将有助于 改进初级预防方案。

DESCRIPTION: The purpose of the proposed research is to establish the aspects of ethnicity that are associated with the differential expression of cardiovascular disease processes in African Americans and Caucasian Americans. Given increasing awareness of the extent to which environments typically faced by these ethnic groups differ, environmental influence on these processes may be an important factor that is an aspect of ethnicity. Socioeconomic status (SES) is a useful index of such environments and is associated with cardiovascular disease (CVD). Since behavior is one pathway through which SES influences are thought to be expressed in disease, this proposal focuses specifically on stress responsivity, which is thought to be linked to the pathophysiology of CVD. Since such disease has its antecedents in childhood, a multiethnic pediatric sample will be employed. In addition, the subject sample will consist of twins. Investigation of the impact of environments on the expression of CVD can be achieved only with proper control for biological influences. Four hundred and eighty twin pairs will visit the laboratory. Half of the pairs will be Africa American, and half Caucasian American; and male and females will be equally represented. Subjects will complete three laboratory stressors: a video game task, a structured social interview, and the cold pressor. Stress responsivity will be assessed, with particular interest being paid to systemic vascular resistance (SVR). Left ventricular mass (LVM) will also be assessed. Sophisticated environmentally and genetically informative analyses will permit quantification of environmental impact upon SVR responsivity and LVM. It is hypothesized that environmental influences (SES) will account for a greater proportion of the variance in SVR responsivity and LVM in African Americans than Caucasian Americans. The hypothesis that SVR responsivity is a pathway through which SES exerts its influence on LVM will also be tested. The long-term objectives are to provide a better understanding of environmental influences on CVD which will aid in the development of improved primary prevention programs.