IRON, FOLATE AND FEMALE COLORECTAL CANCER--COHORT STUDY

描述：(改编自申请人的摘要)：尽管 大量证据表明，饮食中脂肪/肉类含量高，脂肪含量低 水果/蔬菜是结直肠癌风险的重要决定因素， 关于西方饮食的具体方面，人们知之甚少 对增加的风险负责。在这项前瞻性研究中， 申请者寻求确定体内铁的储存和消耗是否增加 正如最近提出的那样，叶酸状态会增加患结直肠癌的风险。 铁在高脂肪/肉类饮食中含量丰富，可催化氧化反应 通过对DNA的损伤产生可能致癌的氧自由基。 铁通常是用来治疗轻微贫血的，尤其是对妇女来说，而且是 包含在许多流行的非处方多种维生素/矿物质药丸中。 叶酸在蔬菜和水果中含量丰富，被认为是微量营养素。 对维持原癌基因表达的正常控制至关重要。 这项拟议的研究将是纽约大学女性研究中心的副产品 健康研究，一项正在进行的由NCI资助的激素和 环境因素与女性慢性病。是否可以使用 这一资源将使调查人员能够在#年进行拟议的研究。 一种非常及时的方式通过获取血液样本和流行病学 在癌症诊断之前已经获得的信息。主 这项建议的目的是评估(1)血清水平是否升高 铁蛋白和转铁蛋白饱和度是最好的 体内铁储存增加的指标；以及(2)血清水平下降 叶酸和血清同型半胱氨酸水平升高与 女性患结直肠癌的风险。这项研究的发现可能会提供 用于设计未来饮食干预措施的科学证据 用于结直肠癌的一级预防。此外，可用性 所有队列成员的基线饮食数据将使调查人员 评估膳食中叶酸和铁的摄入量与 在调整了其他宏观和微观因素后的后续结直肠癌风险 营养素。

DESCRIPTION: (Adapted from the Applicant's Abstract): Despite a substantial body of evidence suggesting a diet high in fat/meat and low in fruit/vegetables as an important determinant of colorectal cancer risk, little is known as to what specific aspects of the Western diet are responsible for the increased risk. In this prospective study, the applicants seek to determine whether increased body iron stores and depleted folate status enhance colorectal cancer risk, as it was proposed recently. Iron, which abounds in high fat/meat diet, catalyses oxidation reactions to produce oxygen radicals that may be carcinogenic by inducing damage to DNA. Iron is often prescribed for minor anemia, especially to women, and is contained in many popular over-the-counter multi-vitamin/mineral pills. Folate, which is plentiful in vegetable and fruits, is micronutrient deemed essential to preserving the normal control of proto-oncogene expression. The proposed study will be a spin off of the New York University Women's Health Study, an ongoing NCI-funded prospective study of hormonal and environmental factors and chronic diseases in women. The availability of this resource will allow the investigators to conduct the proposed study in a very timely fashion by accessing blood specimens and epidemiologic information that has been obtained in advance of cancer diagnosis. The main objectives of this proposal are to assess whether (1) increased serum levels of ferritin and transferrin saturation which are the best available indicators of increased body iron stores; and (2) decreased levels of serum folate and increased serum homocysteine levles are associated with increased colorectal cancer risk in women. The findings from this study could provide scientific evidence to be utilized in design of future dietary interventions for primary prevention of colorectal cancer. In addition, the availability of baseline dietary data for all cohort members will allow the investigators to assess the relationships of dietary intake of folate and iron to subsequent colorectal cancer risk after adjusting for other macro and micro nutrients.