RNA/PROTEIN INTERACTIONS REGULATING MRNA STABILITY
RNA/PROTEIN INTERACTIONS REGULATING MRNA STABILITY
批准号:
2701221
负责人:
MEGERDITCH KILEDJIAN
金额:
$14.84万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-05-01 至 2002-04-30
关键词:
RNA binding protein RNase protection assay alpha globulin chemical stability gel mobility shift assay gene expression genetic regulation genetic regulatory element genetic translation high performance liquid chromatography immunoprecipitation laboratory mouse messenger RNA monoclonal antibody polymerase chain reaction protein purification protein sequence protein structure function ribonucleoproteins tissue /cell culture transcription factor yeast two hybrid system
中文摘要
描述(改编自调查人员摘要)总体目标
这项建议是为了加深对以下决定因素的理解
调节珠蛋白mRNA的稳定性。这项建议有三个主要目的:1)
从生化和遗传两方面鉴定所有的阿尔法复合体蛋白;
2)从功能上研究α-珠蛋白基因的稳定机制
通过使用依赖于α复合体的体外信使核糖核酸衰变系统;以及3)
识别额外的受阿尔法结合并可能受其调控的基因(S)
很复杂。
英文摘要
DESCRIPTION (Adapted from investigators's abstract) The overall objective of
this proposal is to further the understanding of the determinants that
regulate globin mRNA stability. This proposal has three main aims: 1) to
identify all the alpha complex proteins both biochemically and genetically;
2) to functionally characterize the alpha-globin mRNA stability mechanisms
by using an alpha-complex dependent in vitro mRNA decay system; and 3) to
identify additional mRNA(s) bound by and possibly regulated by the alpha
complex.
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会议论文
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依托单位:
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项目类别:
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海外基金