Further Development and Innervation of a 96 Well, 3D, Skin Model for Drug and Toxicity Testing

Alcyomics开发了独特的非动物非人工人类皮肤外植体测定（Skimune & Skimune3D），可以测试新药和化合物（包括化妆品）的安全性和有效性。Skimune和Skimune 3D是通过使用人体皮肤、组织和血液来开发的，因此可以对化合物产生人体反应，而不是目前使用的动物模型。Alcyomics的创新分析方法使制药、化工和化妆品行业的产品能够通过对其安全性的早期评估，更快地进入临床和/或市场。Alcyomics最近在Innovate UK的资助下改进了他们的服务，开发了96井格式的Skimune3D。96孔格式允许高通量筛选，为客户节省了金钱和时间，并且Skimune3D可以在临床试验之前进行多剂量测试和患者药物剂量信息。在目前的项目中，我们的目标是通过生物打印Skimune3D来进一步利用这一模型，并验证生物打印模型的安全性测试，从而创造更标准化的服务。Alcyomics还将与Axol有限公司合作，将神经细胞纳入模型，以便进行神经毒性的安全测试。总而言之，该项目将增加Alcyomics的服务提供和进入新的全球市场和产品开发的道路。

Alcyomics has developed unique non-animal non-artificial human skin explant assays (Skimune & Skimune3D) which can test for safety and efficacy of novel drugs and compounds including cosmetics. Skimune and Skimune 3D have been developed by using human skin, tissue and blood therefore giving a human response to the compounds rather than, the currently used, animal models.Alcyomics innovative assays enable the products of the pharmaceutical, chemical and cosmetic industries to reach the clinic and/or the market place quicker by early assessment of their safety profiles.Alcyomics has recently improved their service offering by the aid of Innovate UK funding by developing Skimune3D in a 96 well format. The 96 well format allows for high throughput screening saving clients both money and time and Skimune3D enables multiple dose testing and information on patient drug dosage prior to clinical trial.In this current project we aim to further exploit this model by bioprinting Skimune3D and validate the bioprinted model for safety testing, therefore creating a more standardised service offering.Alcyomics will also work with Axol Ltd to incorporate nerve cells into the model in order to enable safety testing for neural toxicity.In summary this project will increase Alcyomics' service offering and in roads into new global markets and product development.