IMPLANTABLE BLOOD PRESSURE AND ECG TELEMETRY

根据拟议的努力，植入式遥测发射机将被 开发用于长期监测血压、ECG和 小鼠和其他大小相当的啮齿动物的体温。 的主要重点 该项目是一个应用程序的具体集成开发 用于变送器电子设备的ASIC电路，具有以下能力： 感测多种生理信号，同时实现尺寸目标， 重量、可靠性、测量稳定性和使用寿命。 通过 结合ASIC，发射器将在体内完全可编程， 操作模式和节能功能，将允许其长时间， 用于多个圈养动物的术语。 该项目还将开发一个 小型压力传感导管、改进的封装方法和 在体内对发射器进行编程的装置。 成功完成 拟议的研究将成为生物医学的重要工具。 研究动物生理学的科学家。 概念设计是 申请人现有遥测产品基础的产物， 实验室动物 作为产品，开发的遥测系统将 整合到申请人现有的分销渠道， 目前为30个国家的725家客户提供服务。 拟议商业应用：该器械将提供可靠的， 成本效益的工具，广泛应用于制药 作为一种手段，使用复杂的小鼠模型来评估新的 大药厂 它还将在其他领域进行商业应用 的生物医学研究，其中血压测量是必需的， 从实验室动物，包括制药行业，学术 机构和政府实验室。

Under the proposed effort, an implantable telemetry transmitter will be developed for the chronic monitoring of blood pressure, ECG, and temperature in mice and other comparably-sized rodents. The main focus of the project is the development of an application specific integrated circuit (ASIC) for the transmitter electronics, with the capability of sensing multiple physiological signals, while achieving goals for size, weight, reliability, measurement stability, and operating lifetime. By incorporating an ASIC, the transmitter will be fully programmable in vivo, with operating modes and power-saving features that will permit its long- term use for multiply-housed animals. The project will also develop a small pressure sensing catheter, an improved packaging method, and a device to program the transmitter in vivo. Successful completion of the proposed research will result in an important tool for biomedical researchers involved in whole animal physiology. The conceptual design is an outgrowth of the applicant's existing base of telemetry products for laboratory animals. As a product, the telemetry system developed will be integrated into the applicant's existing distribution channels, which currently services 725 customers in 30 countries. PROPOSED COMMERCIAL APPLICATION: The device will provide a reliable, cost-effective tool for widespread application in the pharmaceutical industry as a means of using sophisticated mouse models for evaluating new pharmaceuticals. It will also have commercial application in other areas of biomedical research, which blood pressure measurements are required from laboratory animals, including pharmaceutical industries, academic institutions, and government labs world-wide.