TOTALLY IMPLANTABLE ARTIFICIAL LUNG

介绍了一种全植入型人工肺。IAL是 旨在全面支持需要长期治疗的成人患者(1- 月)人工有治疗和治疗所需的交换支持 恢复。IAL将为肺移植提供一座桥梁，当 肺部恢复是不可能的。IAL的设计是完全灌流的 当装置与右室平行放置时，右室 天然肺(即至左心房的肺动脉)。一个重要的 与血管内氧合器相比，IAL的优势在于 血管内皮细胞瘤降低了右心室的阻抗。在第一阶段，MC3 原型机几台极低阻力、高效率的人工 并与密歇根大学合作，成功地 在24小时的绵羊实验中植入了10个装置。在第二阶段，和IAL 设计将进行修改，以匹配阻力和合规性 肺循环。设备的几何图形将被修改为 预防血栓形成。将使用定制挤出实心有机硅纤维 以防止血浆泄漏。计划进行广泛的台式测试，包括 流动显示和溶血分析。IAL将在一个 绵羊模型，目标是实现1个月的总换气 支持。 建议的商业应用： 这种设备的商业潜力是巨大的。数量 美国可能成为肺移植候选对象的桥梁目前 超过1,000人，其中50%因可用资源稀缺而被拒绝 供体肺，感染性并发症，只是因为他们不能 忍受手术，从而使手术风险太高，不能 非常珍贵的器官。

A totally implantable artificial lung (IAL) is presented. The IAL is designed to fully support adult human patients who require long term (1- month) artificial has exchange support necessary for treatment and recovery. the IAL will provide a bridge to lung transplantation when lung recovery is impossible. The IAL is designed to be perfused entirely by the right ventricle while the device is placed in parallel with the native lung (i.e., pulmonary artery to left atrium). An important advantage of the IAL over intravascular oxygenators is that the advantage IAL reduces impedance seen by the right ventricle. In Phase I, MC3 prototyped several extremely low resistance, highly efficient artificial lungs, and in collaboration with the University of Michigan, successfully implanted ten devices in 24 -hour sheep experiments. In Phase II, and IAL design will be modified to match resistance and compliance of the pulmonary circulation. The geometry of the device will be modified to prevent thrombosis. Custom-extrusion solid silicone fibers will be used to prevent plasma leakage. Extensive bench testing is planned, including flow visualization and hemolysis analysis. The IAL will be tested in a sheep model, with he goal of achieving 1- month total gas exchange support. PROPOSED COMMERCIAL APPLICATIONS: The commercial potential for this device is extensive. The number of potential bridge to lung transplant candidates in the US is currently over 1,000 of which 50% ar rejected because of scarcity of available donor lungs, infectious complications, and simply because they cannot tolerate the surgical procedure, thereby making them too high a risk for very precious organs.