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ARGININE AMINOPEPTIDASES OF CRYPTOSPORIDIUM PARVUM

ARGININE AMINOPEPTIDASES OF CRYPTOSPORIDIUM PARVUM
小隐孢子虫的精氨酸氨基肽酶
批准号：
6281668
负责人：
Pablo C Okhuysen
金额：
$1.36万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6281668
关键词：
Cryptosporidium aminopeptidase arginine clinical research cryptosporidiosis enzyme activity host organism interaction human subject membrane activity membrane proteins pathologic process protozoal antigen

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中文摘要
翻译
蛋白酶在小隐孢子虫的存活、附着和存活中的作用
英文摘要
The role of proteases in Cryptosporidium parvum survival, attachment, and invasion are unknown. During the funded period of this MCAP study, further characterization of C. parvum aminopeptidase was accomplished. A specific role in parasitic excystation was identified and several inhibitory compounds were found to be effective in preventing amino- peptidase mediated excystation. In addition, basic biochemical characterization, a partial sequence was obtained from a genomic DNA library. Efforts to obtain the complete sequence and protein expression will continue to investigate the immunoreactivity of C. parvum aminopeptidase.
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  • 项目类别：
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  • 负责人：
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  • 依托单位：
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