INTRAVENOUS LIDOCAINE IN TREATMENT OF NEUROPATHIC PAIN SYNDROMES

神经病理性疼痛综合征通常很难治疗。神经病态 疼痛发生在外周和中枢神经损伤之后 系统。患有这些疼痛综合征的患者有各种类型的疼痛 (持续性疼痛、阵发性疼痛、诱发疼痛)，它们在 严肃性。神经病理性疼痛可能伴有不同程度的 相关的感觉和运动缺陷。这些疼痛综合征是已知的 因为他们对标准的疼痛治疗反应很差，包括 鸦片类镇痛剂。最近的报告表明，从系统的角度来看 局部麻醉药可缓解这些症状的疼痛。 然而，目前还不能确定止痛反应是否为剂量和 血药浓度相关。 本项目建议研究获得的止痛与 静脉注射利多卡因及利多卡因血药浓度。在这项研究中 将建立浓度-响应曲线。这样做的结果是 研究将提供如何最佳剂量利多卡因治疗 这些剧痛和难治性疼痛的治疗 综合症。

Neuropathic pain syndromes are often difficult to treat. Neuropathic pain occurs following injury of the peripheral and central nervous system. Patients with these pain syndromes have various types of pains (constant pain, paroxysms of pain, evoked pain), which are variable in severity. Neuropathic pain may be accompanied by variable degrees of associated sensory and motor deficits. These pain syndromes are known for they poor responsiveness to standard pain treatments, including opiate analgesics. Recent reports suggest that systemically administered local anesthetics provide pain relief in these syndromes. However it is not established if the analgesic responses are dose and serum concentration related. This project proposes to study the relation of pain relief obtained with intravenous lidocaine and lidocaine serum concentration. In this study the concentration-response curve will be established. Results of this study will provide information how optimally to dose lidocaine for treatment of these severely painful and treatment resistant pain syndromes.