COHERENCE NEAR-INFRARED UREA BREATH TEST ANALYZER

越来越多的证据表明幽门螺杆菌（以前称为幽门弯曲杆菌）是胃和肠溃疡的原因。 大多数患有溃疡的人都携带这种细菌，根除感染可以治愈疾病，至少在一段时间内。 广泛的人群有感染H.幽门螺杆菌感染，但老年人和发展中国家的人特别容易受到影响。 13 C-尿素呼气试验（UBT）是目前诊断H.幽门感染 智能光学系统（IOS）提出了一种新的，低成本的，便携式近红外CNIR-UBT分析仪，医生可以很容易地在医生的办公室或在医院的病人床边使用。 IOS的CNIR-UBT分析仪基于两项创新技术：（1）创建高光谱分辨率光纤滤波器布拉格光栅 与13 CO2的光谱精确匹配，以及（2）使用压电或电磁拉伸器来调制缠绕在它们周围的光纤的折射率。 所有的系统组件都将是轻量化和紧凑的，并将很容易地安装到手持或便携式台式单元。IOS的CNIR-UBT分析仪代表了一种高度可靠的新技术，将以合理的价格提供给医生。 IOS的CNIR-UBT分析仪基于商用半导体和光纤技术，可以低成本大规模生产。 据估计，美国溃疡诊断的潜在市场为每年1.5亿美元。 目前，内窥镜检查是一种昂贵的侵入性程序，是检测幽门螺杆菌的主要诊断选择;该市场正在经历强劲的增长。

Mounting evidence points toward Helicobacter pylori (formerly called Campylobacter pylori) as the cause of stomach and intestinal ulcers. Most people with ulcers harbor this bacteria, and eradicating the infection cures the disease, at least for a while. A broad spectrum of the population is at risk for H. pylori infection, but the elderly and people in developing countries are especially susceptible. The 13C-urea breath test (UBT) is currently the most accurate noninvasive method for the diagnosis of H. pylori infection. Intelligent Optical Systems (IOS) proposes to demonstrate a new, low-cost, portable near- infrared CNIR-UBT analyzer that a physician can be easily used in physician s offices or at patient bedsides in a hospitals. IOS s CNIR-UBT analyzer is based on two innovative technologies: (1) the creation of high spectral resolution optical fiber filters Bragg gratings that match precisely the spectra of 13CO2, and (2) the use of piezoelectric or electromagnetic stretchers to modulate the refractive index of optical fibers wound around them. All system components will be lightweight and compact, and will easily fit into a handheld or portable bench-top unit. PROPOSED COMMERCIAL APPLICATION IOS s CNIR-UBT analyzer represents a new, highly reliable, technology that will be available to physicians at an affordable price. IOS s CNIR-UBT analyzer is based on commercially available semiconductor and fiber optic technology that will allow the device to be mass produced at low costs. It is estimated that the potential American market for ulcer diagnosis is 150 million dollars per year. Right now endoscopy, a costly, invasive, procedure is the principal diagnostic option for detecting the H.pylori bacterium; this market is experiencing strong growth.