PREPARATION OF NANOPARTICLES OF HYDROXYAPATITE

描述：(改编自申请者摘要)羟基磷灰石(HAP) 具有化学计量比(Ca/P=1.67)和非化学计量比组成 (CA/P&lt；1.67)是一种极好的材料 人工骨和人造牙齿，用于生物-蛋白质的层析分离 大分子和气体传感器。虽然HAP用于人工 骨和牙齿的断裂韧性和静态疲劳破坏 都不能令人满意。获得想要的房产的困难 HAP的来源是它们的准备大多是在 散装水介质中不受控制的成核和颗粒生长 是无法阻止的。这些化合物作为纳米粒子的合成 受约束的微反应器，如油包水的水芯 微乳似乎是一种很有前途的替代方法。 我们提出了一种优化和控制HAP尺寸的方法 通过适当的调制具有窄尺寸分布的纳米级 微乳的某些物理化学条件。这些 用钙磷比、X-射线对羟基磷灰石纳米颗粒进行表征 衍射仪、扫描电子显微镜和透射电子显微镜 显微镜。我们期望更高的密度，更高的强度，以及 用于纳米颗粒衍生样品的微均质HAP陶瓷。这个 烧结纳米羟基磷灰石的力学性能测试 将揭示微乳加工的好处。 建议的商业应用： 最近，我们开发了羟基磷灰石的晶态纳米颗粒。 在第一阶段，我们计划将这些粒子用于各种 生物医学应用在第二阶段。我们将混合纳米晶体 羟基磷灰石在牙科材料中的应用 强度和断裂韧性。而在骨科领域， 合金植入物上的纳米羟基磷灰石涂层将被 以提高它们的生物活性。可再吸收的螺丝和 纳米晶羟基磷灰石颅面骨板 外科应用将改善它们的机械性能。这个 由纳米晶羟基磷灰石和羟基磷灰石制成的种植体的强度 粘结材料，如PMMA，可以制成与强度相等的 骨头做的。

DESCRIPTION: (Adapted from applicant's abstract) Hydroxyapatite (HAp) with compositions of stoichiometric (Ca/P = 1.67) and nonstoichiometric (Ca/P<1.67) is of considerable interest as an excellent material for artificial bones and teeth, for chromatographic separation of bio- macromolecules and for gas sensors. Although HAp is used for artificial bones and teeth but its fracture toughness and static fatigue failure are not satisfactory. The difficulty in obtaining desired properties of HAp stems from the fact that their preparation are mostly done in bulk aqueous media in which uncontrolled nucleation and grain growth cannot be prevented. Synthesis of these compounds as nanoparticle in constrained microreactors such as the aqueous cores of water-in-oil microemulsion seems to be a promising alternative. We have proposed a method to optimize and control the size of HAp on nano-scal with narrow size distribution by a proper modulation of certain physico-chemical conditions of the microemulsion. These nanoparticles of HAp would be characterized by Ca/P ratio, X-ray diffraction, scanning electron microscope, and transmission electron microscope. We expect a higher density, higher strength, and microhomogeneous HAp ceramic for nanoparticle-derived samples. The measurements of mechanical properties of sintered nanoparticles of HAp would reveal the benefits of microemulsion processing. PROPOSED COMMERCIAL APPLICATION: Recently, we have developed crystalline nanoparticles of hydroxyapatite in Phase I. We have planned to use these particles in various biomedical applications in Phase II. We will mix nanocrystalline hydroxyapatite to the dental materials for increasing their tensile strength and fracture toughness. While in area of orthopedic, the coating of nanocrystalline hydroxyapatite on alloy implants will be carried out to increase their bioactivity. The reabsorbable screws and plates made from nanocrystalline hydroxyapatite for craniofacial surgical applications will improve their mechanical properties. The strength of implants developed from nanocrystalline hydroxyapatite and binding materials, such as PMMA, can be made equivalent to the strength of bone.