NEW TOOL FOR PREVENTION THERAPY OF ALZHEIMERS DISEASE

分子计量学提出设计和构建一个X射线衍射 用于测定脂质中抗氧化剂位置的仪器 膜。 该方法是经过验证的，并基于测量 药物吸收膜的电子密度分布的差异 vs.对照样品。在第一阶段期间，分子计量将 测试新型小角度X射线衍射仪设计的可行性 称为角色散X射线衍射（ADiX），它具有 在速度和易用性方面优于其他衍射仪。的 ADiX工具的目的是为研究人员提供， 必须在x射线衍射专家，一个合理的过程， 筛选候选药物的抗氧化潜力，用于预防 老年痴呆症和其他与年龄有关的疾病。 在这个时候， 没有专门用于膜衍射的商业仪器 和结构的确定，然而，根据老龄化的人口统计， 看来，对这种仪器的强烈需求， 医药行业。 建议的商业应用 拟议的仪器将是一个有价值的研究工具， 制药工业用膜的合理测定 用于预防和控制阿尔茨海默氏症的抗氧化剂的活性 疾病和其他与年龄有关的疾病。

Molecular Metrology proposes to design and construct a x-ray diffraction instrument intended to determine the location of antioxidants in lipid membranes. The methodology is proven and is based on the measurement of differences in the electron density profile of drug-imbibed membranes vs. control samples. During the PHASE I period, Molecular Metrology will test the feasibility of a novel small-angle x-ray diffractometer design called Angular Dispersive X-ray Diffraction (ADiX), which has the advantage over other diffractometers in speed and ease of use. The purpose of the ADiX tool is to provide researchers, who are not necessarily experts in x-ray diffraction, a process for the rational screening of antioxidant potential of candidate drugs for the prevention of Alzheimer's disease and other age-related illnesses. At this time, there are no commercial instruments dedicated to membrane diffraction and structure determination, yet, in light of the demographics of aging, there would appear to be a strong need for such instrumentation in the pharmaceutical industry. PROPOSED COMMERCIAL APPLICATION The proposed instrumentation will be a valuable research tool in the pharmaceutical industry for the rational determination of membrane activity for antioxidants used to prevent and control Alzheimer's disease and other age-related illnesses.