MECHANISMS OF DRUG CRAVING--EXPERIMENTAL STUDIES

描述：（申请人摘要） 这项拟议中的研究将探索实验室动物的发展 模型的实验分析的条件下，行为 对渴望的发作和变化的测量受到药物的影响 寻求，吸毒，以及相关环境的时间顺序 事件 渴望在吸毒和吸毒期间复吸中的突出作用 药物戒断使发展和应用的战略， 控制对毒品的渴望是面临的最紧迫的问题之一， 药物滥用治疗和预防。 基本行为指标 包括对反应模式、一般活动、 水平，社会显示，和玩具玩将探讨与 寻找食物和酒精反应的更传统的指标 “力量”在发展一个实验室灵长类动物模型的药物渴望。 这些具有时间敏感性的措施将在直接的条件下进行评估 与食物、首选非酒精饮料和乙醇消费有关， 以及在其中相关联的时间排序 环境刺激的变化，但既不食物，首选非酒精 饮料，也没有乙醇。 连续24小时测量将 使我们有可能调查整个范围内的发病和变化， 在整个白天/夜晚周期中假定的渴望指标低于基线 食品、首选非酒精饮料和乙醇供应时间表 以及在食物有限的情况下，优选不含酒精的 饮料和乙醇的可用性。 这一比较分析将提供 学习中的共性和差异的基本信息， 与食物相关的动机过程，首选非酒精性食物 饮料，乙醇，因为它们涉及到一个有效的， 可靠的实验室灵长类动物药物渴求模型。 的可用性负责 一个动物实验室模型不仅能提供 更深入和广泛的研究，以提高普遍性 关于渴望及其与冒险、侵略和 社会互动，但也将提供一种方法， 潜在有效治疗和预防的临床前评价 对一系列可滥用物质的药物渴望的策略。

DESCRIPTION: (Applicant's Abstract) The proposed research will explore the development of a laboratory animal model for the experimental analysis of the conditions under which behavioral measures of the onset of and changes in craving are influenced by drug seeking, drug taking, and the temporal ordering of associated environmental events. The prominent role of craving in drug taking and in relapse during drug abstinence makes the development and application of strategies for the control of drug craving one of the most pressing problems confronting substance abuse treatment and prevention. Basic behavioral indicators including time-sensitive measures of response patterning, general activity levels, social displays, and toy play will be explored in relationship to more conventional indicators of food- and ethanol-seeking response "strength" in the development of a laboratory primate model of drug craving. These time-sensitive measures will be evaluated under conditions directly related to food, preferred non-alcoholic beverage and ethanol consumption as well as under conditions in which the temporal ordering of associated environmental stimuli changes but neither food, the preferred non-alcoholic beverage, nor ethanol is available. Continuous 24-hour measurements will make it possible to investigate onset and change across the range of putative craving indicators throughout the day/night cycle under baseline food, preferred non-alcoholic beverage, and ethanol availability schedules as well as under conditions of limited food, preferred non-alcoholic beverage, and ethanol availability. This comparative analysis will provide basic information on the commonalities and differences in the learning and motivational processes associated with food, preferred non-alcoholic beverage, and ethanol as they relate to the development of a valid and reliable laboratory primate model of drug craving. The availability of such an animal laboratory model will not only provide the essential building blocks for more intensive and extensive research to enhance generalizable knowledge about craving and its relationship to risk taking, aggression, and social interactions but will as well provide a methodology for the preclinical evaluation of potentially effective treatment and prevention strategies for drug craving over a range of abusable substances.