MODE OF ACTION OF STEROID HORMONES

描述(改编自申请人的摘要)：本提案 重点阐述糖皮质激素受体(GR)与糖皮质激素的关系 糖皮质激素受体的功能和动态变化 与热休克蛋白有关。校长之前的工作 调查人员已经详细确定了GR的地点 磷酸化，并在GR中表现出细胞周期依赖性的变化 磷酸化和热休克蛋白的结合/解离。这个 本提案将扩展这些研究，解决1)GR的作用 GR功能中的磷酸化；2)细胞周期依赖性的作用 在这种磷酸化中的激酶；3)雌激素在 孕激素受体也通过依赖于三磷酸腺苷的周期。

DESCRIPTION (Adapted from the applicant's abstract): This proposal focuses on the relationship between glucocorticoid receptor (GR) function and dynamic transformations of GR by phosphorylation and association with heat shock proteins. Previous work by the principal investigator has identified in detail the sites at which GR is phosphorylated, and has shown cell-cycle dependent changes in GR phosphorylation and heat shock protein association/dissociation. The present proposal will extend these studies, addressing 1) the role of GR phosphorylation in GR function; 2) the role of cell-cycle dependent kinases in this phosphorylation; 3) the possibility that estrogen in progesterone receptors also traverse ATP-dependent cycles.