Understanding sperm motion at surfaces

该项目旨在揭示精子在表面运动的生物物理学，使用3D成像，先进的数学建模和微流体。这个跨学科项目期望产生关于精子鞭毛活动的新知识，使用一种创新的微流体方法来测量精子运动的三维动态，并将实验观察结果与计算结果进行比较。该项目有望揭示鞭毛内的机制，触发三维和二维鞭毛波形之间的切换接近表面。这将提供显著的好处，例如对哺乳动物生殖的生物物理学和真核生物鞭毛运动的起源的重要见解。

This project aims to reveal the biophysics of sperm motion at surfaces, using 3D imaging, advanced mathematical modelling, and microfluidics. This interdisciplinary project expects to generate new knowledge of sperm flagellar activity, using an innovative microfluidic approach to measure full dynamics of sperm motion in 3D and compare experimental observations with computational results. The project is expected to reveal the intraflagellar mechanisms that trigger the switch between 3D and 2D flagellar waveforms near surfaces. This should provide significant benefits, such as important insights into the biophysics of mammalian reproduction and the origin of flagellar motility in eukaryotes.