CORE--DATA COORDINATION

结节病是一种病因不明的全身性肉芽肿性疾病，可能与遗传易感宿主暴露于某些环境因子有关。我们建议确定结节病易感基因，并确定这些基因和环境危险因素如何相互作用，导致结节病。这将通过组织一个多中心联盟来完成，以招募足够的结节病家族样本进行分析。我们计划使用影响同胞对连锁分析扫描基因组的连锁染色体区域，传播不平衡测试，以评估候选基因在这些地区的连锁证据和环境问卷调查收集数据，以测试可能的相互作用的易感基因与外源性风险因素。此应用程序提供了生物统计学和流行病学研究部，亨利福特卫生系统作为数据协调中心（DCC）的项目。DCC将提供行政协调，编写研究文件，制定招募策略，提供研究跟踪，建立中央数据库，进行数据质量保证，并与联合体其他成员合作分析研究结果。数据协调中心（DCC）将是联盟内的一个独立单位，并将接受指导委员会的指导。DCC团队由主要研究者Sarah Fowler博士领导，他是一名高级生物统计学家，专门从事多中心研究的协调中心，协调中心生物统计学家和Co-PI Mei Lu博士将担任DCC的项目经理。DCC联合研究员Marvella福特博士将为合作小组提供关于招募和保留非裔美国人受试者及其家庭的建议。协调中心团队还包括一名支持人员，由多中心研究方法方面经验丰富并致力于此的人员（程序员、数据协调员和秘书）组成。

Sarcoidosis is a systemic granulomatous disease of unknown etiology that likely involves exposure to some environmental agent in a genetically susceptible host. We propose to identify sarcoidosis susceptibility genes and determine how these genes and environmental risk factors interact to cause sarcoidosis. This will be accomplished by organizing a multicenter consortium to recruit an adequate sample of sarcoidosis families for analysis. We plan to use affecting sibling pair linkage analysis to scan the genome for linked chromosomal regions, transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors. This application offers the Department of Biostatistics and Research Epidemiology, Henry Ford Health System as the Data Coordinating Center (DCC) for the project. The DCC will provide administrative coordination, develop study documents, develop recruitment strategies, provide study tracking, establish a central data base, conduct data quality assurance, and collaborate with other members of the consortium in analysis of the results of the study. The Data Coordinating Center (DCC) will be an independent unit within the consortium, and will take guidance from the Steering Committee. The DCC team is headed by Principal Investigator Sarah Fowler, PhD, a senior biostatistical who specializes in coordinating centers for multi-center studies, and coordinating center biostatistician and Co-PI Mei Lu, PhD, who will sere as project manger for the DCC. DCC Co-Investigator Marvella Ford, PhD, will advise the collaborative group on the recruitment and retention of African American subjects and their families. The Coordinating Center team also includes a support staff consisting of individuals (programmer, data coordinator and secretary) experienced in and dedicated to methodologies for multi-center studies.