CORE--DATA COORDINATION

结节病是一种病因不明的全身性肉芽肿性疾病，可能与暴露于某些环境因子的遗传易感宿主有关。我们建议鉴定结节病易感基因，并确定这些基因与环境危险因素如何相互作用导致结节病。这将通过组织一个多中心联盟来招募足够的结节病家族样本进行分析来完成。我们计划使用影响兄弟姐妹对连锁分析扫描基因组以寻找连锁染色体区域，使用传递不平衡测试评估这些区域中具有连锁证据的候选基因，并使用环境问卷收集数据以测试易感基因与外源风险因素之间可能的相互作用。该应用程序提供了生物统计和研究流行病学部门，亨利福特卫生系统作为该项目的数据协调中心（DCC）。DCC将提供行政协调、制定研究文件、制定招聘策略、提供研究跟踪、建立中央数据库、进行数据质量保证，以及与联盟其他成员合作分析研究结果。数据协调中心（DCC）将是联盟中的一个独立单位，并将接受指导委员会的指导。DCC团队由首席研究员Sarah Fowler博士领导，她是一名高级生物统计学家，专门负责协调多中心研究的中心，协调中心生物统计学家和联合pi Mei Lu博士将担任DCC的项目经理。DCC联合调查员马维尔拉·福特博士将为非裔美国人及其家庭的招募和保留提供合作小组的建议。协调中心团队还包括一个由个人（程序员、数据协调员和秘书）组成的支持人员，他们在多中心研究方法方面经验丰富，并致力于此。

Sarcoidosis is a systemic granulomatous disease of unknown etiology that likely involves exposure to some environmental agent in a genetically susceptible host. We propose to identify sarcoidosis susceptibility genes and determine how these genes and environmental risk factors interact to cause sarcoidosis. This will be accomplished by organizing a multicenter consortium to recruit an adequate sample of sarcoidosis families for analysis. We plan to use affecting sibling pair linkage analysis to scan the genome for linked chromosomal regions, transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors. This application offers the Department of Biostatistics and Research Epidemiology, Henry Ford Health System as the Data Coordinating Center (DCC) for the project. The DCC will provide administrative coordination, develop study documents, develop recruitment strategies, provide study tracking, establish a central data base, conduct data quality assurance, and collaborate with other members of the consortium in analysis of the results of the study. The Data Coordinating Center (DCC) will be an independent unit within the consortium, and will take guidance from the Steering Committee. The DCC team is headed by Principal Investigator Sarah Fowler, PhD, a senior biostatistical who specializes in coordinating centers for multi-center studies, and coordinating center biostatistician and Co-PI Mei Lu, PhD, who will sere as project manger for the DCC. DCC Co-Investigator Marvella Ford, PhD, will advise the collaborative group on the recruitment and retention of African American subjects and their families. The Coordinating Center team also includes a support staff consisting of individuals (programmer, data coordinator and secretary) experienced in and dedicated to methodologies for multi-center studies.