THE HORMONAL CONTROL OF FETAL GROWTH

描述(改编自申请人的摘要)：申请人 建议测量神经元的大小和数量的变化以及它们 他的转基因小鼠TTHC中的树突和轴突。要确定 IGF-I影响神经发育的机制，他将 检测IGF-I在体内对a)神经细胞增殖和 迁移，b)神经元凋亡，c)I型受体的调节 以及d)可能调节这些变化的候选基因的表达 由IGF-I诱导。还将研究IGFBPs的调制效应 使用初级神经元研究。最后，申请者将测试 IGF-I表达或作用减少的假说 营养不良的脑部病理。他预测IGF-I过度表达 IGFBP-1的表达将会改善和加剧营养不良 对货柜码头处理费的影响。

DESCRIPTION (Adapted from the applicant's abstract): The applicant proposes to measure changes in the size and number of neurons and their dendrites and axons in the TThC in his transgenic mice. To determine the mechanisms by which IGF-I influences neural development, he will examine IGF-I's in vivo effects on a) neuronal cell proliferation and migration, b) neuronal apoptosis, c) the regulation of type I receptors and d) the expression of candidate genes that may mediate the changes induced by IGF-I. The modulatory effects of IGFBPs will also be studied using primary neuronal studies. Finally, the applicant will test the hypothesis that decreases in IGF-I expression or actions mediate the brain pathology of malnutrition. He predicts that IGF-I overexpression will ameliorate and IGFBP-1 expression will exacerbate malnutrition's effects on the TThC.