CORE--CRYSTALLOGRAPHY

描述：(申请人描述)晶学设备提供了测定小分子(如多肽或配体)和大分子(如蛋白质或核酸)的晶体结构的能力。个别研究小组生产的晶体进行了衍射测试，并分析了衍射分辨率的程度。X射线衍射数据是通过小分子的衍射仪测量和大分子的多丝面探测器或成像板探测器收集的。隶属于结晶学设施的结晶学家直接与用户互动，设计出确定感兴趣分子的晶体结构的策略。这一信息对研究所一些项目的正在进行的研究至关重要。

Description: (Applicant's Description) The Crystallography Facility offers the capability for determination of the crystal structure of small molecules (e.g., peptides or ligands), as well as macromolecules (i.e., proteins or nucleic acids). Crystals produced by individual research groups are tested for diffraction and analyzed for the extent of diffraction resolution. X-ray diffraction data are collected by diffractometer measurements for small molecules and by multiwire area detectors or imaging plate detectors for macromolecules. The crystallographers affiliated with the Crystallography Facility interact directly with users to devise strategies to determine the crystal structures of interesting molecules. This information is critical to the ongoing research of a number of Institute projects.