Core--Clinical pharmacology

产品描述：（申请人的描述）临床药理学分析机构（CPAF）成立于1994年，为匹兹堡大学癌症研究所（UPCI）的成员提供最先进的药理学研究机构。 CPAF与临床药理学中心共享约2300平方英尺的实验室面积。 CPAF人员使用所有临床药理学实验室中心（样本采集/分析实验室、质谱、分子生物学和细胞培养实验室）以及UPCI的梅里尔Egorin博士实验室。 CPAF为UPCI研究者的临床前和临床研究项目提供支持，包括分析服务，以测定临床样本中的药物、代谢物和其他内源性产物;鉴定未知药物代谢物;以及在UPCI进行I/II期试验的抗癌药物的药代动力学和药效学研究。 与临床药理学中心的分子生物学设施合作，CPAF正在对正常志愿者和各种实体瘤患者外周血单核细胞中细胞色素P450亚型和其他关键药物代谢酶的表达进行表型和基因分型。 Egorin博士在临床前和临床抗癌药物药理学方面的专业知识为该设施提供了额外的临床前和临床能力。CPAF还为UPCI研究人员提供药理学研究设计和药物测定、代谢和药代动力学分析方面的咨询服务。

Description: (Applicant's Description) The Clinical Pharmacology Analytical Facility (CPAF) was established in 1994 to provide state of the art pharmacology research facilities for members of the University of Pittsburgh Cancer Institute (UPCI). The CPAF shares the laboratory area of approximately 2300 sq ft with the Center for Clinical Pharmacology. All Center for Clinical Pharmacology laboratories, (sample collection/analytical laboratory, mass spectrometry, molecular biology, and cell culture laboratory) as well as Dr. Merrill Egorin's laboratories in UPCI are utilized by the CPAF personnel. The CPAF provides support for preclinical and clinical research programs of UPCI- investigators, including analytical services to assay drugs, metabolites and other endogenous products in clinical samples; identification of unknown drug metabolites; and pharmacokinetics and pharmacodynamic studies of anticancer agents undergoing Phase I/II trials at UPCI. In collaboration with the Molecular Biology Facility of the Center for Clinical Pharmacology, the CPAF is phenotyping and genotyping the expression of cytochrome P450 isoforms and other key drug metabolizing enzymes in peripheral blood mononuclear cells of normal volunteers and patients with a variety of solid tumors. Dr. Egorin's expertise in preclinical and clinical anticancer drug pharmacology provides additional preclinical and clinical capability of this facility. The CPAF also provides consultation services to UPCI investigators on the design of pharmacologic studies and drug assay, metabolism and pharmacokinetics analysis.