SURGICAL STUDIES OF GI PEPTIDES--MECHANISMS OF ACTION

描述：GI肽是普遍存在的物质，其中许多是 对上皮细胞生长和发育有营养作用。 这些肽调节 它们与特定受体结合后的作用。 虽然有一些 交叉反应性，独特受体的出现和表征 可以提供对细胞增殖控制的更好理解。 这一提议用于表征一种独特的胃泌素相关受体， G/G-Gly R，它似乎与CCK-B受体不同， 具体性和行动。 更好地了解这种受体及其 位置以及细胞增殖的机制可以允许使用 新的无毒形式的抗肿瘤治疗胃肠道癌症。

DESCRIPTION: GI peptides are ubiquitous substances, many of which are trophic for epithelial cell growth and development. These peptides modulate their effects after binding to specific receptors. Although there is some cross reactivity, the emergence and characterizations of unique receptors may provide better understanding into control of cellular proliferation. This proposal serves to characterize a unique gastrin associated receptor, G/G-Gly R, which appears to be distinct from the CCK-B receptor in its specificity and action. Better understanding of this receptor and its location, as well as mechanisms for cellular proliferation may allow the use of novel non-toxic forms of anti-neoplastic therapy in GI tract cancers.