ACTIVITY INTERVENTION IN WOMEN A DECADE LATER

描述：(改编自《调查人员摘要》)十年前，一个 临床试验结束了，这项试验一直在检查步行的效果 匹兹堡229名绝经后妇女的骨密度干预。 在2.5年的研究结束时，干预妇女被发现 根据活动调查，比对照女性更活跃 活动监视器。这项临床试验的一个里程碑是它 80%的干预妇女达到了创纪录的遵从性 报告称，估计每周平均步行5英里。 两年半的临床试验。参加比赛的女性 最初的临床试验于1995年重新联系，并由 电话了解他们目前的活动水平和健康状况；90%的人 最初的参与者被成功追踪到。基于 报告的活动数据显示，女性似乎进行了干预 与对照组相比，保持更高的体力活动水平 女人。此外，注意到的一个显著差异是 两个随机分组报告的10年心脏病发病率 疾病。干预组中的两名女性报告患有心脏病 与11名对照妇女相比(相对风险=0.18)。这样做的目的是 目前的申请是再次联系这些女性以验证 报告的冠心病发病率差异很大 两个随机组之间的关系，并确定两个 干预组在体力活动的客观测量上有所不同， 冠心病危险因素和骨密度。心脏病会 通过对医院报告的评估得到证实，医生 有人脉和丰富的病史。体力活动监测器 将在这项研究中使用，以获得当前的客观测量 活动。骨密度(AP腰椎、股骨近端和全身) 全身软组织成分将由双能量决定 X射线吸光度测定法。将进行超声波扫描，以 测定颈动脉的动脉粥样硬化程度。 心血管危险因素，如血脂、全身脂肪、空腹 胰岛素和葡萄糖浓度，以及静息血压也会 在两组之间进行测量和比较。调查人员 声明这项研究旨在解决公众的一个重要领域 并将是第一个研究Long的临床试验 中等强度运动对老年女性的长期影响。

DESCRIPTION: (Adapted from Investigator's Abstract) Ten years ago, a clinical trial ended, which had been examining the effects of a walking intervention on bone density in 229 post-menopausal women in Pittsburgh. At the end of the 2.5 year study, the intervention women were found to be more active than the control women based upon activity surveys and activity monitors. A milestone of this clinical trial was that it achieved record-setting compliance with 80% of the intervention women reporting a minimum weekly walking estimate of 5 miles averaged over the 2.5 years of the clinical trial. The women who participated in the original clinical trial were re-contacted in 1995 and interviewed by phone to obtain their current activity levels and health status; 90% of the original participants were successfully traced. Based upon the reported activity data, the intervention women appeared to have maintained higher physical activity levels compared to the control women. In addition, there was a striking difference noted between the two randomized groups in the 10-year incidence of reported heart disease. Two women in the intervention group reported heart disease compared to 11 control women (relative risk=0.18). The purpose of this current application is to contact these women again to validate the large differences in incidence of coronary heart disease reported between the two randomized groups and to determine if the two intervention groups differ by objective measures of physical activity, coronary heart disease risk factors and bone density. Heart disease will be validated through an evaluation of hospital reports, physician contacts and extensive medical histories. Physical activity monitors will be utilized in this study to obtain an objective measure of current activity. Bone density (AP lumbar spine, proximal femur and whole-body) and whole-body soft-tissue composition will be determined by dual energy x-ray absorptiometry. Ultrasound scanning will be performed to determine the level of atherosclerosis in the carotid arteries. Cardiovascular risk factors such as lipids, total body fat, fasting insulin and glucose concentrations, and resting blood pressure will also be measured and compared between the two groups. The investigators state that the study is designed to address an important area of public health and would be the first clinical trial to investigate the long term effects of moderate intensity exercise in older women.