PRESSURE AND FLOW IN THE RETINAL CIRCULATION

描述(摘自申请者的摘要)：视网膜疾病 血管系统是许多视网膜疾病的主要因素，但 对视网膜血管压控制及其力学的认识 缺乏通过视网膜毛细血管的血液流动。申请人 建议继续使用伺服微穿刺术进行研究 视网膜微血管压和毛细血管流量的控制。 此外，一种新的高分辨率玻璃体内成像系统 将使用视网膜毛细血管的可视化技术。三个研究方向是 建议。在一线学习中，申请者将完成他的基础 视网膜血管压力控制的研究，在第二次他 将开始研究在毛细管水平上控制流动的因素。 第三条线的工作将涉及开发一个数学模型 视网膜循环作为了解视网膜的一个框架 发行量。为研究其对血管的影响而施加的条件 参数将包括眼压升高、等容 血液稀释、高血糖、血管闭塞等手法 旨在阐明视网膜血管的基本机制和位置 功能。猫被用在这些研究中是因为比较 它们的视网膜和视网膜血管系统与人类相似。这个 预计这一发现将对视网膜疾病有影响 循环成分，如青光眼、糖尿病和视网膜阻塞 疾病。

DESCRIPTION (Adapted from applicant's abstract): Disorders of the retinal vasculature are major factors in many retinal diseases, but basic understanding of the control of retinal vascular pressure and the mechanics of blood flow through retinal capillaries is lacking. The applicant proposes to continue use of the servonull micropuncture technique to study the control of microvascular pressure and capillary flow in the retina. Additionally, a new high resolution intravitreal imaging system for visualizing the retinal capillaries will be used. Three lines of study are proposed. In the first line of study, the applicant will complete his basic studies of the control of retinal vascular pressures, and in the second he will begin to examine the factors that control flow at the capillary level. The third line of effort will involve development of a mathematical model of the retinal circulation as a framework for understanding retinal circulation. Conditions to be imposed to study their effects on vascular parameters will include elevated intraocular pressure, isovolemic hemodilution, hyperglycemia, vascular occlusion and other manipulations designed to illuminate fundamental mechanisms and sites of retinal vascular function. Cats are used in these studies because of the comparative similarities of their retina and retinal vasculature to that in humans. The findings are expected to have implications for retinal diseases with circulatory components such as glaucoma, diabetes and retinal occlusive disease.