HISTONE LIKE PROTEINS ASSOCIATED WITH KINETOPLAST DNA

描述（改编自申请人的摘要）：动质体原生动物是 内脏和皮肤利什曼病、昏睡病的病原体 和南美锥虫病的流行。这些 寄生生物体的特征是具有独特形式的线粒体DNA 称为动质体DNA或kDNA。这些DNA由数千个 小环和大约25个大环，所有这些都联锁成一个 一种浓缩成高度有序的盘状结构的单一DNA网络 鞭毛基部的结构。环状DNA分子被释放出来 分别从网络中复制，然后重新加入网络 当所有的环状DNA分子变成 复制的然后将双倍大小的网络分成两个和一个统一大小的网络 网络被划分为两个子单元中的每一个， 细胞分裂本研究将探讨这一群体的作用， 组蛋白样动基体蛋白在组织和分离的 KDNA在动质体Crithidia fasciculata。

DESCRIPTION (Adapted from the Applicant's Abstract): Kinetoplastid protozoa are the causative agents of visceral and cutaneous leishmaniasis, sleeping sickness and Chagas' disease in much of the tropical and subtropical world. These parasitic organisms are characterized by a unique form of mitochondrial DNA called a kineplast DNA or kDNA. This DNA consists of several thousand minicircles and about 25 maxicircles, all of which are interlocked into a single DNA network which is condensed into a highly organized disk-shaped structure at the base of the flagellum. Circular DNA molecules are released individually from the network, replicated and then rejoined to the network which eventually doubles in size as all circular DNA molecules become duplicated. The double sized network is then divided into two and a united size network is partitioned to each of two daughter cells prior to completion of cell division. This research will investigate the role of the group of histone-like kinetoplast proteins in the organization and segregation of the kDNA in the kinetoplastid Crithidia fasciculata.