EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

这项申请寻求联邦配套资金来完成建设 医学研究中心目前七楼的壳体空间 匹兹堡大学设施(MRF)，毗邻 生物医学科学塔(BST)。MRF和BST共同构成了 该机构的大部分研究空间。申请的资金 将允许装修大约20,000平方英尺的总面积 实验室将容纳基础和基础设施的核心教师 匹兹堡关节炎大学的临床研究项目 研究中心，最近接受了一种多功能关节炎和 NIAMS提供的肌肉骨骼疾病中心资助。提供这一空间用于 关节炎研究中心将把基础和临床结合起来 来自两个部门(内科和整形外科)的调查人员将 对关节炎和肌肉骨骼疾病的共同兴趣以及 补充性研究培训。该中心的使命是 促进实验室和临床之间的密切互动 调查人员开发并高效地探索创新方法 用来治疗关节炎。这个小组的一个主要重点是 细胞因子基因治疗的临床应用及首次临床应用 一种非致命性疾病--类风湿性关节炎--的基因治疗试验 目前正在匹兹堡大学由这个团体表演。 目前，这些调查人员的实验室和办公室是 分散在整个校园，严重阻碍了互动，以及 目前没有合适的空间来创建这个多- 学科研究中心。临床研究的空间特别大 有限和连续的研究空间不能用于招聘 所需的额外教员(可获得资金) 扩大该中心的项目。后一个问题，也就是短缺 可用研究空间的不足，对规划产生了负面影响 包括传染病在内的其他重要领域的发展 研究中心，重点研究急性炎症的发病机制和 艾滋病毒治疗的新方法和该司的基因图谱计划 旨在调查病因的胃肠病和肝病学 炎症性肠病和胰腺炎。拟议的设施将 通过提供新的空间来满足机构的这些关键需求 关节炎研究中心有整合和扩展的空间 它的研究计划，并通过提供这些腾出的空间 传染病学科发展规划的探讨 研究中心和消化内科。

This application seeks federal matching funds to complete the construction of current shell space on the seventh floor in the Medical Research Facility (MRF) of the University of Pittsburgh, which adjoins the Biomedical Science Tower (BST). The MRF and the BST together comprise the major majority of research space at the institution. The requested funds will permit up-fitting of approximately 20,000 gross square feet of space for laboratories which will house the core faculty of the basic and clinical research programs of the University of Pittsburgh Arthritis Research Center, the recent recipient of a Multipurpose of Arthritis and Musculoskeletal Diseases Center grant from NIAMS. Providing this space for the Arthritis Research Center will bring together basic and clinical investigators from two Departments (Medicine and Orthopaedic Surgery) will common interests in arthritis and musculoskeletal diseases and complementary research training. The mission of the Center is to facilitate close interactions between laboratory and clinical investigators to develop and then efficiently explore innovate approaches to the treatment of arthritis. A major emphasis of this group is the clinical application of cytokine-based gene therapy and the first clinical trial of gene therapy for a non-lethal disease, rheumatoid arthritis, is currently being performed at the University of Pittsburgh by this group. At present, the laboratories and offices of these investigators are dispersed throughout the campus, significantly hampering interactions, and suitable space does not currently exist for the creation of this multi- disciplinary research center. Space for clinical research is particularly limited and contiguous research space is not available for recruitment of additional faculty (for which funds are available) that are necessary to expand the programs of the Center. This latter problem, namely a shortage of available research space, is negative impacting programmatic development in other important areas including an Infectious Disease Research Center with a focus on the pathogenesis of acute inflammation and novel approaches to HIV therapy and a gene-mapping program in the Division of Gastroenterology and Hepatology designed to investigate the etiologies of inflammatory bowel disease and pancreatitis. The proposed facility will satisfy these critical needs of the institution by providing new space for the Arthritis Research Center with room for integration and expansion of its research programs and by making available the space vacated by these investigators to the developing programs of the Infectious Diseases Research Center and the Division of Gastroenterology.