ENDOGENOUS SEROTONIN AND GUT TRANSPORT

我们的实验室感兴趣的是内源性5-羟色胺在 它与肠道运输和运动有关。我们有大量的 使用大鼠结肠模型，并计划将我们的工作扩展为 以下是： 1.我们将描述释放和运输响应的特征 内源性5-羟色胺通过粘膜刺激释放。 2.根据使用大鼠结肠制剂获得的信息，我们 将描述生理性5-羟色胺在人空肠中的作用 采用新的隔离灌流组织模型。 3.同时，我们将研究生理性5-羟色胺对大鼠心脏功能的影响。 用原位动物模型研究大鼠的肠道运输和运动。

Our laboratory is interested in the role of endogenous serotonin as it relates to gut transport and motility. We have extensive experience with a rat colon model, and plan to expand our work as follows: 1. We will characterize the release and transport response to endogenous 5-HT released via mucosal stimulation. 2. Based on the information learned using rat colon preparations we will delineate the function of physiologic 5-HT on human jejunum using novel isolated perfused tissue model. 3. Concurrently, we will study the effects of physiologic 5-HT on rat bowel transport and motility using an in situ animal model.