HEART-LUNG PHYSIOLOGY: MOLECULAR-SYSTEMIC INTEGRATION

这是培训心血管和呼吸系统综合生理学研究生和博士后研究员的新应用。该计划的目标是为一批经过挑选的博士后和博士后学员提供在分子、细胞、器官以及整个动物和人类层面上的心-呼吸系统功能整合方面的强化和出色的培训。拟议计划的主要优势是培训教师的可用性和他们研究动物心肺系统生理学的能力，通过有针对性的基因操作，允许将遗传和分子生物学信息整合到生理功能中。该项目有来自凯斯西储大学医学院6个基础系和2个临床科学系的19名教职员工。这些课程包括生理学和生物物理学、神经科学、营养学、生物医学工程、解剖学、生物化学、医学和儿科学。许多参与的教员进行了长期富有成效的协作互动，并以跨学科的方式培养了一批成功的研究和内科科学家。它们都有活跃的和有充分基础的实验室，利用人类和/或动物模型提供最先进的心肺生理学研究培训。这一培训计划将是一种将这些研究人员聚集在一起的机制，并将对心肺生理学的培训和未来的研究产生重大影响。本申请面向8名博士后和/或博士后实习生。博士前学生将被录取为新开发的系统集成生理学研究生项目的博士生。博士前培训包括专门为心肺生理学、分子和细胞生物学基础、实验室轮换、研讨会和指导性研究的综合方面而设计的高级课程。该项目的博士后实习生有三种：1)医学博士进入专门的博士项目；2)心脏病和/或肺部临床研究员作为博士后实习生接受2年的全日制研究；3)博士后实习生。特别高级课程、活跃的研讨会和期刊俱乐部将补充博士后培训。我们认为，我们建议的培训计划，强调跨越部门障碍和科学学科，对于成功培训研究人员在心肺系统生理学的综合方面是必要的。

This is a new application for training graduate and post-doctoral fellows in integrated physiology of cardiovascular and respiratory systems. The goal of this program is to provide a selected group of pre and postdoctoral trainees with intensive and excellent training in integration of function of the cardio-respiratory systems at the molecular, cellular, organ and whole animal and human levels. The major strength of the proposed program is the availability of training faculty and their ability to study physiology of the cardio-respiratory systems in animals with targeted manipulation of genes allowing integration of genetic and molecular biological information into physiological functions. There are 19 participating faculty in this program from 6 basic and 2 clinical science departments at the School of Medicine at Case Western Reserve University (CWRU). These include Physiology & Biophysics, Neurosciences, Nutrition, Biomedical Engineering, Anatomy, Biochemistry, Medicine, and Pediatrics. Many of the participating faculty has long term productive collaborative interactions and trained a number of successful research and physician-scientists in an interdisciplinary manner. They all have active and well-founded laboratories providing state-of-the-art research training in cardiopulmonary physiology using human and/or animal models. This training program will be a mechanism to bring together these investigators and will have a major impact on training and future research in cardio-pulmonary physiology. This application seeks eight pre- and/or postdoctoral trainees. The predoctoral students will be enrolled as Ph.D. students in a newly developed Systems Integrated Physiology graduate program. Predoctoral training includes advanced courses specifically designed for integrated aspects of cardio- respiratory physiology, fundamentals of molecular and cell biology, laboratory rotations, seminars, and guided research. Postdoctoral trainees in this program are of three kinds: 1) MD's entering a specialized Ph.D. program; 2) cardiology and/or pulmonary clinical fellows receiving 2 years full time research as postdoctoral trainees; 3) Ph.D. postdoctoral trainees. Special advanced courses, active seminar sessions and journal clubs will supplement postdoctoral training. We believe, our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines is necessary for the successful training of researchers in integrated aspects of the physiology of the cardio-respiratory systems.