The Training in Oxygen in Health and Disease

描述（由申请人提供）：这是一份重新提交的机构培训资助申请，用于在芝加哥大学培训与健康与疾病中O2生物学相关的研究前和博士后。原理：了解氧气感知机制和细胞氧气需求的决定因素是许多疾病过程的基础。最近的进展为我们对细胞如何感知O2的理解提供了范式转变，也为生物体如何适应O2环境变化的分子基础提供了惊人的见解。O2生物学的转化潜力吸引了生物学和医学各个学科的研究人员的注意，并且绝对需要为下一代基础科学家和内科科学家提供O2生物学的研究培训。该计划的目标是a)为学员提供O2生物学领域的广泛基础，包括O2传感、O2病理生物学、缺血再灌注和活性氧生物学；b)为学员在基础和/或临床研究、学术教学和/或生物技术领域从事有竞争力的职业做好准备。被推荐的教师已经在一个或多个O2生物学领域建立了研究项目，并培养了许多成功的科学家。培训师资包括5个临床科室和3个基础科室。该培训计划建立在拟议教员之间的现有合作基础上，并通过与O2生物学相关的合作研究促进培训。招收博士预科2名，博士后5名。博士预科生将从一个或多个博士学位授予委员会中招收，招收的博士后培养人员包括：1)博士博士后培养人员；2)医学、儿科、外科、放射肿瘤学、麻醉等临床奖学金项目招收的医学博士；3)医学博士。我被招募到医学系的医师-科学家发展项目。研修生和博士后都将学习O2生物学的跨学科课程，以及核心课程、研讨会和期刊俱乐部。除了研究之外，还将提供拨款和写作技巧方面的培训，使他们成为独立的科学家。我们提出的培养方案强调跨越部门壁垒和科学学科，将培养出全面发展的O2生物学人才，具有基础和转化意义。

DESCRIPTION (provided by applicant): This is a re-submission of a new application for an Institutional training grant to train pre-and post doctoral fellows at the University of Chicago in research related to O2 Biology in Health & Disease. Rationale: Understanding the mechanisms of O2 sensing and determinants of cellular O2 requirements are fundamental to many disease processes. Recent advances provided a paradigm shift in our understanding of how cells sense O2, and also spectacular insights into the molecular basis for how organisms adapt to changes in O2 environment. The translational potential of O2 biology attracted the attention of researchers in various disciplines of Biology & Medicine and there is an absolute need to provide research training in O2 biology to the next generation of basic and physician scientists. The goals of the program are a) to provide trainees with a broad foundation in the O2 biology in the areas of O2 sensing, O2 Patho-biology, Ischemia-Reperfusion, and Biology of reactive oxygen species and b) to prepare trainees to pursue competitive careers in basic and/or clinical research, teaching in academia and/or the biotechnology field. The proposed faculty members have established research programs in one or more areas of O2 biology and have trained a number of successful scientists. The training faculty represents 5 clinical and 3 basic science departments. This training program is built upon existing collaborations amongst the proposed faculty and fosters training through collaborative research related to O2 biology. We request 2 pre-doctoral and 5 post-doctoral positions. The pre-doctoral trainees will be recruited from one or more of the Ph.D. awarding committees, and Post-doctoral trainees recruWed will include: 1) Ph.D. post-doctoral trainees, 2) MDs recruited in clinical fellowship programs in Medicine, Pediatrics, Surgery, Radiation-oncology, and Anesthesia and 3) MD-Ph.D.s recruited into the Physician-Scientist Development Program in the Department of Medicine. Both pre-and post doctoral trainees will be offered an interdisciplinary course in O2 Biology along with core curriculum, seminars and Journal clubs. In addition to research, training in grants-manship and writing skills will be offered enabling them to become independent scientists. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, will develop well-rounded scientists trained in O2 biology, which has basic and translational significance.