The Training in Oxygen in Health and Disease

描述(由申请人提供)：这是一份新的机构培训补助金申请，旨在培训芝加哥大学的博士后和博士后研究员，从事与健康和疾病中的氧气生物学相关的研究。理论基础：了解氧气感知的机制和细胞氧气需求的决定因素是许多疾病过程的基础。最近的进展使我们对细胞如何感知O2的理解发生了范式转变，也为生物体如何适应O2环境的变化提供了壮观的分子基础。O2生物学的翻译潜力吸引了生物学和医学各个学科的研究人员的注意，绝对有必要为下一代基础和内科科学家提供O2生物学的研究培训。该计划的目标是：a)为学员提供氧气传感、氧气病理生物学、缺血-再灌流和活性氧生物学方面的广泛基础；b)为学员在基础和/或临床研究、学术和/或生物技术领域从事有竞争力的职业生涯做好准备。拟议的教职员工在O2生物学的一个或多个领域建立了研究计划，并培养了许多成功的科学家。培训教师包括5个临床科室和3个基础科学科室。这一培训计划建立在提议的教职员工之间现有的合作基础上，并通过与O2生物学相关的合作研究来促进培训。我们需要2个博士后和5个博士后职位。博士后实习生将从一个或多个博士授予委员会中招募，Wed将招募的博士后实习生将包括：1)博士后实习生，2)医学、儿科、外科、放射肿瘤和麻醉学临床奖学金计划中招募的MD，3)医学博士-博士被招募到医学系的医生-科学家培养计划。博士后和博士后实习生都将被提供氧气生物学的跨学科课程以及核心课程、研讨会和期刊俱乐部。除了研究，还将提供赠款技巧和写作技能方面的培训，使他们能够成为独立的科学家。我们建议的培训计划强调跨越部门障碍和科学学科，将培养受过氧气生物学培训的全面发展的科学家，这具有基础和翻译意义。

DESCRIPTION (provided by applicant): This is a re-submission of a new application for an Institutional training grant to train pre-and post doctoral fellows at the University of Chicago in research related to O2 Biology in Health & Disease. Rationale: Understanding the mechanisms of O2 sensing and determinants of cellular O2 requirements are fundamental to many disease processes. Recent advances provided a paradigm shift in our understanding of how cells sense O2, and also spectacular insights into the molecular basis for how organisms adapt to changes in O2 environment. The translational potential of O2 biology attracted the attention of researchers in various disciplines of Biology & Medicine and there is an absolute need to provide research training in O2 biology to the next generation of basic and physician scientists. The goals of the program are a) to provide trainees with a broad foundation in the O2 biology in the areas of O2 sensing, O2 Patho-biology, Ischemia-Reperfusion, and Biology of reactive oxygen species and b) to prepare trainees to pursue competitive careers in basic and/or clinical research, teaching in academia and/or the biotechnology field. The proposed faculty members have established research programs in one or more areas of O2 biology and have trained a number of successful scientists. The training faculty represents 5 clinical and 3 basic science departments. This training program is built upon existing collaborations amongst the proposed faculty and fosters training through collaborative research related to O2 biology. We request 2 pre-doctoral and 5 post-doctoral positions. The pre-doctoral trainees will be recruited from one or more of the Ph.D. awarding committees, and Post-doctoral trainees recruWed will include: 1) Ph.D. post-doctoral trainees, 2) MDs recruited in clinical fellowship programs in Medicine, Pediatrics, Surgery, Radiation-oncology, and Anesthesia and 3) MD-Ph.D.s recruited into the Physician-Scientist Development Program in the Department of Medicine. Both pre-and post doctoral trainees will be offered an interdisciplinary course in O2 Biology along with core curriculum, seminars and Journal clubs. In addition to research, training in grants-manship and writing skills will be offered enabling them to become independent scientists. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, will develop well-rounded scientists trained in O2 biology, which has basic and translational significance.