The Training in Oxygen in Health and Disease

描述（由申请人提供）：这是一个机构培训补助金的新申请的重新提交，以培训前和博士后研究员在芝加哥大学在研究相关的健康与疾病的O2生物学。原理：了解O2传感机制和细胞O2需求的决定因素对许多疾病过程至关重要。最近的进展为我们理解细胞如何感知O2提供了一个范式转变，也为生物体如何适应O2环境变化的分子基础提供了惊人的见解。O2生物学的转化潜力吸引了生物学和医学各学科研究人员的注意，绝对需要为下一代基础和医生科学家提供O2生物学的研究培训。该计划的目标是a）在O2传感，O2病理生物学，缺血-再灌注和活性氧生物学领域为学员提供广泛的O2生物学基础，B）为学员准备在基础和/或临床研究，学术界和/或生物技术领域的教学中追求有竞争力的职业生涯。拟议的教职员工已经在O2生物学的一个或多个领域建立了研究计划，并培养了一些成功的科学家。培训教师代表5个临床和3个基础科学部门。该培训计划建立在拟议教师之间现有的合作基础上，并通过与O2生物学相关的合作研究促进培训。我们要求2个博士前和5个博士后职位。博士预科生将从一个或多个博士生中招募。奖励委员会，和博士后研究生招聘将包括：1）博士学位。博士后实习生，2）医学博士在医学，儿科，外科，放射肿瘤学和麻醉学的临床奖学金计划招募和3）医学博士-博士招募到医学系的医生-科学家发展计划。博士前和博士后学员将提供O2生物学的跨学科课程，沿着核心课程，研讨会和期刊俱乐部。除了研究之外，还将提供赠款和写作技能方面的培训，使他们能够成为独立的科学家。我们提出的培训计划，强调跨部门的障碍和科学学科，将培养全面的科学家在O2生物学，这具有基础和转化的意义。

DESCRIPTION (provided by applicant): This is a re-submission of a new application for an Institutional training grant to train pre-and post doctoral fellows at the University of Chicago in research related to O2 Biology in Health & Disease. Rationale: Understanding the mechanisms of O2 sensing and determinants of cellular O2 requirements are fundamental to many disease processes. Recent advances provided a paradigm shift in our understanding of how cells sense O2, and also spectacular insights into the molecular basis for how organisms adapt to changes in O2 environment. The translational potential of O2 biology attracted the attention of researchers in various disciplines of Biology & Medicine and there is an absolute need to provide research training in O2 biology to the next generation of basic and physician scientists. The goals of the program are a) to provide trainees with a broad foundation in the O2 biology in the areas of O2 sensing, O2 Patho-biology, Ischemia-Reperfusion, and Biology of reactive oxygen species and b) to prepare trainees to pursue competitive careers in basic and/or clinical research, teaching in academia and/or the biotechnology field. The proposed faculty members have established research programs in one or more areas of O2 biology and have trained a number of successful scientists. The training faculty represents 5 clinical and 3 basic science departments. This training program is built upon existing collaborations amongst the proposed faculty and fosters training through collaborative research related to O2 biology. We request 2 pre-doctoral and 5 post-doctoral positions. The pre-doctoral trainees will be recruited from one or more of the Ph.D. awarding committees, and Post-doctoral trainees recruWed will include: 1) Ph.D. post-doctoral trainees, 2) MDs recruited in clinical fellowship programs in Medicine, Pediatrics, Surgery, Radiation-oncology, and Anesthesia and 3) MD-Ph.D.s recruited into the Physician-Scientist Development Program in the Department of Medicine. Both pre-and post doctoral trainees will be offered an interdisciplinary course in O2 Biology along with core curriculum, seminars and Journal clubs. In addition to research, training in grants-manship and writing skills will be offered enabling them to become independent scientists. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, will develop well-rounded scientists trained in O2 biology, which has basic and translational significance.