The Training in Oxygen in Health and Disease

健康与疾病中的氧气训练

• 批准号: 8279310
• 负责人: Nanduri R Prabhakar
• 金额: $ 26.32万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279310
• 关键词: Disease; Health; Oxygen; Training

DESCRIPTION (provided by applicant): This is a re-submission of a new application for an Institutional training grant to train pre-and post doctoral fellows at the University of Chicago in research related to O2 Biology in Health & Disease. Rationale: Understanding the mechanisms of O2 sensing and determinants of cellular O2 requirements are fundamental to many disease processes. Recent advances provided a paradigm shift in our understanding of how cells sense O2, and also spectacular insights into the molecular basis for how organisms adapt to changes in O2 environment. The translational potential of O2 biology attracted the attention of researchers in various disciplines of Biology & Medicine and there is an absolute need to provide research training in O2 biology to the next generation of basic and physician scientists. The goals of the program are a) to provide trainees with a broad foundation in the O2 biology in the areas of O2 sensing, O2 Patho-biology, Ischemia-Reperfusion, and Biology of reactive oxygen species and b) to prepare trainees to pursue competitive careers in basic and/or clinical research, teaching in academia and/or the biotechnology field. The proposed faculty members have established research programs in one or more areas of O2 biology and have trained a number of successful scientists. The training faculty represents 5 clinical and 3 basic science departments. This training program is built upon existing collaborations amongst the proposed faculty and fosters training through collaborative research related to O2 biology. We request 2 pre-doctoral and 5 post-doctoral positions. The pre-doctoral trainees will be recruited from one or more of the Ph.D. awarding committees, and Post-doctoral trainees recruWed will include: 1) Ph.D. post-doctoral trainees, 2) MDs recruited in clinical fellowship programs in Medicine, Pediatrics, Surgery, Radiation-oncology, and Anesthesia and 3) MD-Ph.D.s recruited into the Physician-Scientist Development Program in the Department of Medicine. Both pre-and post doctoral trainees will be offered an interdisciplinary course in O2 Biology along with core curriculum, seminars and Journal clubs. In addition to research, training in grants-manship and writing skills will be offered enabling them to become independent scientists. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, will develop well-rounded scientists trained in O2 biology, which has basic and translational significance.

描述（由申请人提供）：这是对机构培训补助金的新申请的重新提出，以培训芝加哥大学的博士前和博士后研究员，研究与健康与疾病的O2生物学有关的研究。理由：了解O2传感和细胞O2要求的决定因素的机制是许多疾病过程的基础。最近的进步提供了我们对细胞如何感知O2的理解，以及对生物如何适应O2环境变化的分子基础的壮观见解。 O2生物学的转化潜力吸引了研究人员在生物学和医学各个学科中的关注，并且绝对需要向下一代基础和医师科学家提供O2生物学的研究培训。该计划的目标是a）在O2传感，O2病情生物学，缺血 - 重新灌注以及反应性氧和b的生物学领域为受训者提供广泛的基础。拟议的教职员工已经在O2生物学的一个或多个领域建立了研究计划，并培训了许多成功的科学家。培训教师代表5个临床和3个基础科学部门。该培训计划建立在拟议的教职员工之间的现有合作之上，并通过与O2生物学有关的协作研究培养培训。我们要求2个博士后和5个博士后职位。博士学位的学员将从博士学位的一个或多个。授予委员会和博士后学员将包括：1）博士学位。博士后学员，2）医学博士在医学，儿科，手术，放射障碍和麻醉方面的临床奖学金计划中招募，以及3）MD-PH.D.D.D.D.D.D.D.D。两位博士后学员都将获得O2生物学的跨学科课程以及核心课程，研讨会和期刊俱乐部。除研究外，还将提供赠款和写作技巧的培训，使他们能够成为独立的科学家。我们提出的培训计划强调了部门障碍和科学学科的穿越，它将开发经过O2生物学培训的全面科学家，该科学具有基本和翻译的意义。