TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY

提出了一个发展生物学的博士后和博士后研究培训计划，重点是细胞、分子和遗传机制。该计划是跨部门、多学科的，涉及弗吉尼亚大学的教职员工和实习生，主要来自文理学院的生物系和医学院的细胞生物学、微生物学和神经科学计划。目前对教师在发育生物学方面的培训支持是不够的，拟议的培训计划被视为整个大学在发展生物学方面令人兴奋和不断扩大的努力的重要组成部分，涉及：1)新聘用的教员，他们对发育生物学以及细胞和分子生物学、生物化学和发育遗传学相关领域的研究和培训感兴趣；2)由大学和国家科学基金会支持的重大改造项目，使发育教师的实验室达到现代标准，为培训提供了良好的设施；3)成立发育生物学计划，这是一个跨部门组织，其目标是促进发育生物学家之间更强有力的研究和培训互动与合作，并对研究生和博士后研究人员进行更有成效的招聘和指导。培训人员多种多样，但相辅相成，并在关键领域提供广泛而综合的培训。这些包括基因表达的调控、细胞信号、细胞与组织的相互作用、胚胎的诱导和构型、细胞的决定和分化，以及形态发生的许多方面，如细胞膜融合、细胞-基质相互作用、细胞骨架、细胞运动、细胞黏附和细胞极性。所使用的系统包括果蝇、蚱蜢、两栖动物、鸟类、老鼠、培养细胞和几种植物。使用了遗传学、分子、细胞、生理学和生物物理学的方法，特别强调遗传学。大多数工作是基础科学，但有几个项目，在医学院的临床部门完成，具有医学应用。因此，教师提供了广阔的视野，广泛的研究机会，以及丰富的培训和职业发展环境。过去，他们在培养博士后和博士后学生从事独立研究方面非常成功。为10名博士后和6名博士后实习生申请资金，以便以竞争性方式授予最有前途的候选人。支持研究生或博士后前3年的学习，且培训进展良好，或直至获得个人奖项。

A pre-doctoral and post-doctoral research training program in developmental biology with an emphasis on cellular, molecular, and genetic mechanisms is proposed. The program is interdepartmental, multi- disciplinary, and involves faculty and trainees at the University of Virginia, primarily from the Departments of Biology in the College of Arts and Sciences and from Cell Biology, Microbiology, and the Neurosciences Program in the School of Medicine. The current training support available to faculty in developmental biology is inadequate, and the proposed training program is seen as an important part of an exciting and expanding University-wide effort in developmental biology that involves: 1) new hires of faculty with research and training interests in developmental biology and in related areas of cell and molecular biology biochemistry and developmental genetics; 2) major renovation projects, supported by the University and the NSF, that have brought the laboratories of development faculty up to modern standards providing excellent facilities for training; 3) formation of the Developmental Biology Program, an interdepartmental organization with the goals of fostering stronger research and training interactions and collaborations among developmental biologists and to carry out more productive recruiting and mentoring of graduate students and post- doctoral researchers. The training faculty are diverse but complementary are diverse but complementary, and offer broad but integrated training in key areas. These include regulation of gene expression, cell signaling, cell and tissue interactions, embryonic induction and patterning, cell determination and differentiation, and many aspects of morphogenesis, such as cell membrane fusion, cell-matrix interaction, cytoskeleton, cell motility, cell adhesion, and cell polarity. The systems used include Drosophila, grasshopper, amphibians, birds, mice, cultured cells, and several plants. Genetic, molecular, cellular, physiological and biophysical approaches are used, with a strong emphasis in genetics. Most work is basic science but several projects, done in clinical departments of the School of Medicine, have medical applications. Thus the faculty provide a broad perspective, a wide selection of research opportunities, and a rich environment for training and career development. In the past they have been highly successful in training both pre and post-doctoral students for independent research careers. Funds are requested for 10 pre-doctoral and 6 postdoctoral trainees to be awarded competitively to the most promising candidates. Support will be for the fist 3 years of graduate student or post- doctoral study, with the condition of good progress in training, or until individual awards are obtained.