HEMATOLOGY CLINICAL RESEARCH TRAINING GRANT

宾夕法尼亚大学血液学研究培训计划成立于1978年，目前已进入第19个资助年，最近四年一直由现任首席研究员Lawrence Brass负责。在这段时间里，我们的目标一直是帮助对广泛定义的血液学学科感兴趣的优秀候选人，以及最近的血管生物学，为他们的学术生涯做好准备，他们在实验室的科学训练可以应用于实验室或临床研究。在前19年的资助中，70名博士后学员和1名博士预科学员在33个不同的实验室工作：57名医学博士，9名医学博士。其中女性20人，男性51人。在64名已完成培训的受训者中，41名（64%）在学术机构全职任职，从事实验室（22%）或临床（42%）研究。另有7人（11%）主要从事临床实践，但有大学任命，参与临床研究项目和兼职教学。其余25%则因各种原因没有工作（5%）、从事工业（3%）或从事全职私人执业（17%）。大约有一半的前受训者获得校外研究资助，本年度的直接费用超过700万美元。该项目的毕业生在美国21个机构任职，包括宾夕法尼亚大学、哈佛大学和美国国立卫生研究院。现有正教授3人，副教授11人，助理教授20人，讲师4人。该提案提供了自奖助金开始以来所有受训者的后续信息，并描述了该计划在过去二十年中的发展情况。基于迄今为止培训计划的成功，更多优秀候选人的可用性，以及血液学和血管生物学教师和项目的增长，该提案还提出了从目前的5名医学博士，医学博士-博士增加资金的案例。博士、博士后职位每年8个。

The Hematology Research Training Program at the University of Pennsylvania was established in 1978 and is currently in its 19th year of funding, the last four of which have been under the current principal investigator, Lawrence Brass. Throughout that time, the goal has been to help top candidates with an interest in the broadly-defined disciplines of hematology and, more recently, vascular biology to prepare themselves for academic careers in which their scientific training in laboratories could be applied to either laboratory or clinical research. During the first 19 years of funding, 70 postdoctoral trainees and one pre-doctoral trainee have been supported for work in 33 different laboratories: 57 M.D., 9 M.D.-Ph.D. and 4 Ph.D. Twenty of the trainees were women, 51 were men. Of the 64 trainees who have completed training to date, 41 (64%) hold full-time appointments at an academic institution and are engaged in either laboratory (22%) or clinical (42%) research. An additional 7 (11%) are engaged primarily in clinical practice, but have university appointments and participate in clinical research projects and teaching part-time. The remaining 25% are either not working for a variety of reasons (5%), employed in industry (3%) or engaged in full time private practice (17%). Approximately half of our former trainees have extramural research funding with direct costs in the current year exceeding $7 million. Graduates of this program hold appointments at 21 institutions around the United States, including the University of Pennsylvania, Harvard and the NIH. Among the program graduates there are currently 3 full professors, 11 associated professors, 20 assistant professors and 4 instructors. This proposal provides follow-up information on all of the trainees since the inception of the grant and describes how the program has evolved during the past two decades. Based on the success of the training program to date, the availability of additional strong candidates, and the growth of the faculty and programs in hematology and vascular biology, this proposal also makes the case for an increase in funding from the current 5 M.D., M.D.-Ph.D. and Ph.D. postdoctoral positions per year to 8 per year.