MEDICATION ADHERENCE INTERVENTION FOR HIV+ PERSONS

研究人员建议利用先前的最佳策略， 坚持和行为改变研究开发和干预试验 这将评估144名艾滋病毒感染的男性和女性， 坚持抗逆转录病毒疗法的患者， 两个条件之一：一个量身定制的行为团体干预 由行为心理学家和执业护士协助， 包括社会支持和患者教育，或标准护理 条件 该方案涉及广泛的干预，所以复发 预防被认为是长期坚持所必需的，因此， 干预包括五个会议最初和四个助推器 会议随后。 所有参与者将在术前/术后进行评估- 干预时间点为3个月、9个月、15个月和21个月。 本研究的目的是：（1）确定定制行为是否 包括社会支持和患者干预的干预 组件和维护助推器会议，促进药物治疗 依从性和与药物相关的情感问题解决 长期随访中HIV阳性者的依从性;（2） 以确定随着时间的推移在 干预组;（3）确定是否改善药物治疗 坚持与情绪和行为的证据较少相关 苦恼，生活质量更好;（4）探讨如何用药 坚持与性传播风险行为相关;（5） 探索药物依从性和潜在的 调节和中介变量，包括自我效能和结果 与依从性、行为意图、应对方法相关的接受度， 和医疗保健满意度。

The investigators proposed to utilize the best strategies from prior adherence and behavior change research to develop and intervention trial that will evaluate 144 HIV-infected men and women having difficulty adhering to their antiretroviral regimen, who will be randomly assigned to one of two conditions: a tailored behavioral group intervention facilitated by behavioral psychologist and a nurse practitioner which includes social support and patient education, or a standard care condition. The protocol involves an extensive intervention, so relapse prevention is thought to be needed for long term adherence, thus the intervention consists of five sessions initially and four booster sessions subsequently. All participants will be assessed at pre/post- intervention time points at three, nine, fifteen, and twenty-one months. The aims of the study are: (1) to determine whether tailored behavioral intervention that includes social support and patient intervention components, and maintenance booster sessions, promotes medication adherence, and affective problem solving related to medication compliance among HIV positive individuals over long term follow-up; (2) to determine the level of adherence that is maintained over time in the intervention group; (3) to determine if improvement in medication adherence is associated with less evidence of emotional and behavioral distress, and better quality of life; (4) to explore how medication adherence is associated with sexual transmission risk behaviors; and (5) to explore relationships between medication adherence and potential moderating and mediating variables, including self-efficacy and outcome acceptances related to adherence, behavioral intentions, coping methods, and health care satisfaction.