THERAPY GROUPS TO STUDY T-CELL DEPLETION OF DONOR MARROW

这份合同是一项关于T细胞耗尽的研究的一部分 供者骨髓移植。主要目标是 确定是否减少急性和非传染性疾病的发病率和死亡率 慢性移植物抗宿主病(GvHD)可在 患者接受来自非亲属捐赠者的T细胞耗尽骨髓 在没有平衡白血病复发增加的情况下 移植物衰竭。这项前瞻性、随机性研究将需要 共有560名患者。研究人员将随机对患者进行调查 T细胞耗尽或不耗尽。每个治疗组都会 利用他们自己的方法来耗尽T细胞。两个重要的因素 这项研究的组成部分是描述移植的 关于移植物中细胞的数量和类型，以及 来监测免疫重建。本项目包括4种疗法 小组和一个医疗协调中心。这项研究是预期的 可以持续七年半。

This contract is part of a study of T cell-depletion in unrelated donor bone marrow transplantation. The primary objective is to determine if a reduction in morbidity and mortality from acute and chronic graft versus host disease (GvHD) can be achieved in patients given T cell-depleted marrow from an unrelated donor without a counterbalancing increase in relapse of leukemia and graft failure. This prospective, randomized study will require a total of 560 patients. Study investigators will randomize patients to T cell-depletion or no-depletion. Each therapy group will utilize their own method of T cell-depletion. Two important components of this study are to characterize the transplanted marrow with regard to numbers and types of cells in the graft, and to monitor immune reconstitution. This project includes 4 therapy groups and a medical coordinating center. This study is expected to last seven and one-half years.