MICROVASCULAR VASOACTIVITY IN THE RENAL MEDULLA

描述：(改编自《调查者摘要》)这是一个修订版 第一个研究腺苷在调节血液中的作用的奖项 在肾髓质中流动。其具体目的是考察 CAMP在介导A1和A2激动剂对离体灌流血管直径的影响 2)观察肾缺血对肾功能的影响。 肾髓质内腺苷水平及对体内髓质血流的影响； 3)确定钠饮食变化对肾腺苷的影响 肾脏的水平和区域血流；4)绘制腺苷图谱 肾髓质小管和血管结构中的受体亚型。 这些研究应该有助于提供有关该角色的重要新信息 腺苷在控制脊髓血流量和氧输送中的作用 在尿液发生机制中起关键作用的肾髓质 浓度、钠和水的排泄与动脉血流量的控制 压力。

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a revised first award that will investigate the role of adenosine in regulating blood flow in the renal medulla. The specific aims are to examine the role of cAMP in mediating A1 and A2 agonists on the diameter of isolated perfused vasa recta capillaries; 2) to determine the effects of renal ischemia on adenosine levels in the renal medulla and on medullary blood flow in vivo; 3) to determine the effects of changes in sodium diet on renal adenosine levels and regional blood flow in the kidney and; 4) to map adenosine receptor subtypes in tubular and vascular structures in the renal medulla. These studies should contribute important new information regarding the role of adenosine in the control of medullary blood flow and oxygen delivery to the renal medulla which plays a critical role in the mechanism of urine concentration, sodium and water excretion, and the control of arterial pressure.