RESTORATION OF MUSCLE FUNCTION DURING REHABILITATION

描述(改编自申请者摘要)：尽管 肌肉功能障碍的发生及其对运动成绩的显著影响 在日常活动中，人们对这种机制知之甚少。 参与肌肉功能的恢复。康复服务 肌肉功能主要依赖于经验证据。因此， 这项建议的总体目标是阐明生理上的 肌肉功能和功能恢复的机制 性能。研究人员假设，肌肉的改善 康复过程中的功能和功能表现直接 与体内代谢特性和总代谢的改变有关 骨骼肌的形态。为此，30名患者 在脚踝手术后接受5-10周的石膏固定 接受为期10周的康复计划。在…的过程中 康复31P-磁共振波谱(MRS)，磁共振 磁共振成像(MRI)、肌肉活检、肌肉功能和功能 将执行性能测试。创新本地化31P-MRS 将实施测量来测量肌肉的变化 体内也有通过有氧和无氧方式提供能量的能力 因为它在收缩过程中管理能量的能力。此外，3- 将使用三维MRI程序来量化 最大肌肉横截面积和总肌肉体积 康复的过程。这些体内能量测量指标的变化 供应、能量需求和肌肉形态将与变化相关 在标准的体外测量中。最终，体内的变化 训练过程中肌肉能量学和肌肉形态的测量 康复将与肌肉功能的改善和 功能性能。肌肉耐力、力量和力量将是 以标准的等长和等速测试为特征，而 日常活动中的表现将通过SIMPLE 任务，如爬楼梯，步行和一条腿的脚趾抬起。这个 调查人员预计，BASIC和APPLICAL组合使用 康复过程中骨骼肌的测量，如 本研究的提出，将有助于阐明生理学 肌肉功能恢复的潜在机制。此外, 他们预计，这项研究将为 设计和开发更具体的康复干预措施 它专注于潜在的病理生理学，提供了更快的 重新融入社区。

DESCRIPTION (Adapted from the Applicant's Abstract): Despite the high occurrence of muscle dysfunction and its dramatic effect on performance in daily ambulatory activities, little is known about the mechanisms involved in the restoration of muscle function. Rehabilitation of muscle function has mainly relied on empirical evidence. Therefore the overall goal of this proposal is to elucidate the physiological mechanism underlying the restoration of muscle function and functional performance. The investigators hypothesize that improvements in muscle function and functional performance during rehabilitation are directly related to alterations in the in vivo metabolic properties and gross morphology of skeletal muscle. For this purpose, 30 patients who underwent 5-10 weeks of cast immobilization following ankle surgery will be subjected to a 10 week rehabilitation program. During the course of rehabilitation 31P-Magnetic Resonance Spectroscopy (MRS), Magnetic Resonance Imaging (MRI), muscle biopsy, muscle function and functional performance tests will be performed. Innovative localized 31P-MRS measurements will be implemented to measure changes in the muscle's in vivo ability to supply energy via aerobic and anaerobic means as well as its ability to manage energy during contraction. In addition, 3- dimensional MRI procedures will be used to quantify the changes in maximal muscle cross-sectional area and total muscle volume during the course of rehabilitation. Changes in these in vivo measures of energy supply, energy demand and muscle morphology will be related to changes in standard in vitro measures. Ultimately, changes in the in vivo measures of muscle energetics and muscle morphology during the course of rehabilitation will be related to improvements in muscle function and functional performance. Muscular endurance, power and strength will be characterized by standard isometric and isokinetic tests, whereas the performance in daily ambulatory activities will be evaluated via simple tasks such as stair climbing, walking and one legged toe raises. The investigators anticipate that the combined use of basic and applied measures of skeletal muscle during the course of rehabilitation, as proposed in this study, will help to elucidate the physiological mechanisms underlying the restoration of muscle function. In addition, they anticipate that this study will provide essential feedback for the design and development of more specific rehabilitation interventions which focus on the underlying pathophysiology, providing a faster reintegration into the community.