MUTAGENICITY TESTING IN SALMONELLA

本合同的目标是测试大约25个 每年使用体外沙门氏菌进行致突变性的化学品 致突变试验 沙门氏菌测试已被广泛接受， 一种化学物质在高等生物中潜在诱变性的指标， 和致癌性。 测试的化学品将选自 在拟定的致突变性、致癌性或 生殖毒性试验，或特别感兴趣的 国家毒理学计划或国家毒理学研究所的其他机构 环境卫生科学。 从该合同中获得的结果将用于协助 确定短期和长期动物试验的优先事项，并将 提供资料，说明支持《公约》的行动机制， 长期动物毒性结果的解释。 完成 这些研究也将使遗传学的进一步发展 毒性数据库，用于确定一致性水平 体内和体外遗传毒性试验之间的差异及其预测性 啮齿类动物致癌作用的体外结果。

The objective of this contract is to test approximately twenty-five chemicals per year for mutagenicity using the in vitro Salmonella mutagenicity test. The Salmonella test has become widely accepted as an indicator of a chemical's potential mutagenicity in higher organisms, and of carcinogenicity. The chemicals tested will be selected from among those that are proposed for mutagenicity, carcinogenicity, or reproductive toxicity testing, or are of special interest to the National Toxicology Program or others in the National Institute of Environmental Health Sciences. The results obtained from this contract will be used to assist in setting priorities for short- and long-term animal testing, and will provide information on mechanisms of action to support the interpretations of long-term animal toxicity results. Completion of these studies will also allow for the further development of the genetic toxicity database which will be used to determine the level of agreement between in vivo and in vitro genetic toxicity tests and the predictivity of in vitro results for rodent carcinogenesis.