COGNITION IN AGING AND ALZHEIMERS DISEASE--AN FMRI STUDY

描述(改编自调查人员摘要)：许多组件 阿尔茨海默病(AD)对认知的影响，两种特殊的认知 具有特殊临床相关性的领域：情景记忆测试(延迟 回忆和识别)对检测AD高度敏感，并且测试 语义检索(命名和流利性)最有利于疾病的分期和 追踪它的进程。记录解剖学和生理学 活着的受试者中这些损伤的相关性提供了对 脑部潜在解剖和功能性病变的分布 会产生广告。推行这一方法，从而扩大理解 关于衰老和阿尔茨海默病的脑-行为关系，研究人员建议 在三年内进行一系列与认知测试相关的实验 在这两个领域的表现对海马体积和模式的影响 用功能磁共振成像测量神经激活。

DESCRIPTION (adapted from investigator's abstract): Of the many components of cognition affected in Alzheimer's disease (AD), two particular cognitive domains have special clinical relevance: tests of episodic memory (delayed recall and recognition) are highly sensitive for detecting AD, and tests of semantic retrieval (naming and fluency) are best for staging the disease and tracking its progression. Documenting the anatomical and physiological correlates of these impairments in the living subject gives insights into the distribution of the underlying anatomical and functional brain lesions that produce AD. To pursue this approach, and thereby extend understanding of brain-behavior relations in aging and AD, the investigators propose to conduct a series of experiments over 3 years relating cognitive test performance in these two domains to hippocampal volume and to patterns of neural activation measured with functional magnetic resonance imaging.