MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

所附申请提出，母胎医学（MFM） 大学妇产科系 辛辛那提医学中心（UCMC）的研究人员被选为继续在 母胎医学单位合作多中心网络（MFMU）。 在目前的资助期间，MFMU团队成功地筛选了， 招募、实施和收集所有试验的数据， MFMU指导委员会。此外，MFM教师一直在 有助于建立新的临床试验方案， 由MFMU执行。大辛辛那提医疗保健联盟， 包括UCMC，基督医院（TCH），圣卢克医院 (SLH)，UCMC管理人员，MFM部门成员， 新生儿科、内科、病理科、 生物统计学、遗传学和流行病学渴望继续其 与MFMU成员在MFMU临床试验中的互动。 MFM部门 在UCMC建立了密切合作的优良传统 与其他UCMC部门在规划和实施过程中， 美国国立卫生研究院（NIH）资助的许多联合项目。 MFM部门的学术优势是全国公认的， 学院的教职员均为学术精英，的 科内临床医生和基础科学家的组合 为有意义的合作研究提供了理想的环境， 允许在临床试验中解决当前的围产期问题 而基本的科学问题在实验室里研究。1994年 妇产科（Ob/Gyn）全国排名第二 在接受NIH研究资金的妇产科部门中。花墟 UCMC的教师和服务得到了全国知名的 新生儿教师认为，重要的和悬而未决的问题， 围产期保健只能通过精心计划的产前检查来解决 临床试验这两个学院不仅享有强大的临床， 研究和培训联系，但大辛辛那提大都会 该地区是独一无二的，因为有一个完善和成功的 围产期-新生儿外联方案，确保所有人都能转诊 给加州大学医学院的MFMU做了复杂的怀孕报告UCMC的承诺和 儿童医院医学中心（CHMC）的研究是例证 成立了围产期研究所， 专门用于围产期和发育研究。的中心主题 该研究所是“预防低出生体重儿问题”， 这也是NIH MFMU网络的主要目标。 每年有超过6000名初级和转诊患者在UCMC和TCH就诊 其中30%是高危人群。这个人口远远超过了 由RFA设定;此外，所有患者均可招募， MFMU网络临床试验。我们在当前的招聘成功 网络表明我们有足够的能力， 保持合作多中心的成功成员 母胎医学单位网络。

The attached application proposes that the Maternal-Fetal Medicine (MFM) Division of the Department of Obstetrics and Gynecology at the University of Cincinnati Medical Center (UCMC) be selected for continuation in the Cooperative Multicenter Network of Maternal-Fetal Medicine Units (MFMU). In the current funding period, the MFMU team has successfully screened, recruited, implemented, and collected data for all trials initiated by the MFMU steering committee. Furthermore, the MFM faculty has been instrumental in establishing new protocols for clinical trials to be conducted by the MFMU. The Health Care Alliance of Greater Cincinnati, consisting of the UCMC, the Christ Hospital (TCH), the St. Luke Hospital (SLH), UCMC administrators, members of the MFM Division, the Division of Neonatology, the Departments of Internal Medicine, Pathology, Biostatistics, Genetics, and Epidemiology are eager to continue its interaction with MFMU members in MFMU clinical trials. The MFM Division at the UCMC has established an excellent tradition of close cooperation with the other UCMC Departments during the planning and implementation of numerous joint programs funded by the National Institutes of Health (NIH). The academic strengths of the MFM Division are nationally recognized, and the faculty are well established and committed to academic pursuits. The combination of clinicians and basic scientists within the Division provides an ideal environment for meaningful collaborative research, allowing for current perinatal problems to be addressed in clinical trials while basic scientific issues are studied in the laboratory. In 1994, the Department of Obstetrics and Gynecology (Ob/Gyn) ranked second nationally among Departments of Ob/Gyn receiving NIH funding for research. The MFM faculty and services at UCMC are enhanced by a nationally-renowned neonatal faculty who believe that important and unresolved issues of perinatal care can only be solved by carefully planned prnspectjve clinical trials. Not only do the two faculties enjoy strong clinical, research, and training links, but the Greater Cincinnati Metropolitan region is unique in that there is a well established and successful Perinatal-Neonatal Outreach Program which ensures referral of all complicated pregnancies to the MFMU at UCMC. The commitment of UCMC and the Children's Hospital Medical Center (CHMC) to research is exemplified by the establishment of the Perinatal Research Institute devoted exclusively to perinatal and developmental research. The central theme of the Institute is the "prevention of problems in low birth weight infants," the major objective also of the NIH MFMU Network. Over 6000 primary and referral patients are seen at UCMC and TCH each year of whom 30% are high risk. This population far exceeds the requirements set by the RFA; furthermore, all patients are available for recruitment to the MFMU Network clinical trials. Our recruitment success in the current Network demonstrates that we have more than sufficient capabilities and resources to remain a successful member in the Cooperative Multicenter Network of Maternal-Fetal Medicine Units.