SPECT MAMMOGRAPHY USING ROTATING SLANT HOLE COLLIMATOR

描述（改编自申请人的摘要）：在本申请中， 申请人仔细地阐述了所提出的SPECT的重要应用 乳腺癌分期和表征技术。初步结果 从一个原型RMSSH准直器。此外，一个新的具体目标和 方法进行初步临床试验的建议技术是 补充说所提出的SPECTM技术的创新包括：（1）使用 一个MSSH准直器，提供3至4倍的检测效率， 它的视野比具有相同空间的传统准直器 分辨率，（2）通过以下方式获取完整投影数据集的能力 简单地旋转MSSH在2至3个位置上的90度弧周围 乳房，（3）RMSSH准直器靠近乳房的能力 在数据采集过程中获得最佳空间分辨率，以及（4）充分利用 重建完整投影数据集的3D重建方法， 提供高质量、定量准确和无伪影的重建 图像.研究设计和方法包括：（1）设计专用 优化的SPECTM技术的MSSH准直器，（2）开发 完整投影的传输和发射数据采集策略 使用旋转MSSH准直器的数据集，（3）开发 全三维重建方法，提供定量准确的 乳房的重建图像，（4）评估3D SPECTM图像， 小的和低收缩的乳腺病变的检测和表征， 和（5）SPECTM技术在5个国家的初步试验性临床评价 患者建议的新SPECTM技术可以很容易地实现在大多数 核医学诊所只需要低成本（约20，000美元） 准直器组件。它将大大提高评估 乳腺癌的程度和特征，用于分期目的， 在乳腺癌的手术治疗中是有用的。

DESCRIPTION (Adapted from Applicant's Abstract): In this application, the applicants carefully addressed the important application of the proposed SPECT technique in breast cancer staging and characterization. Preliminary results from a prototype RMSSH collimator were included. Also, a new specific aim and methods to conduct an initial clinical trial of the proposed technique were added. The innovations of the proposed SPECTM technique include: (1) the use of a MSSH collimator that provides 3 to 4 times the detection efficiency within its field-of-view than a conventional collimator with the same spatial resolution, (2) the ability to acquire complete sets of projection data by simply rotating the MSSH at 2 to 3 positions on a 90 degree arc around the breast, (3) the ability for the RMSSH collimator to stay close to the breast during data acquisition for best spatial resolution, and (4) the use of fully 3D reconstruction methods that reconstruct the complete projection data sets to provide high quality, quantitatively accurate and artifact-free reconstructed images. The research design and methods include: (1) the design of special optimized MSSH collimators for the SPECTM technique, (2) the development of transmission and emission data acquisition strategies for complete projection data sets from using the rotating MSSH collimators, (3) the development of fully 3D reconstruction methods that provide quantitatively accurate reconstructed images of the breast, (4) evaluation of the 3D SPECTM images for the detection and characterization of small and low contract breast lesions, and (5) initial pilot clinical evaluation of the SPECTM technique in five patients. The proposed new SPECTM technique can be easily implemented in most nuclear medicine clinics requiring only a low cost (about $20,000) RMSSH collimator assembly. It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer.